Literature DB >> 862771

The absolute configuration of SU 23397: a novel neuroleptic agent.

N K Chaudhuri, T J Ball, N Finch.   

Abstract

The absolute configuration of a novel chiral neuroleptic agent SU 23397 (I) was determined by ORD comparison of (+)-5-methoxy dihydro coumarilic acid (VIII), a synthetic precursor of SU 23397 (I), with (+)-dihydro coumarilic acid, whose absolute configuration is known. This assignment was confirmed by oxidative degradation of (+)-5-methoxy dihydro coumarilic acid VIII to D-(+)-malic acid.

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Year:  1977        PMID: 862771     DOI: 10.1007/bf01946504

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  6 in total

1.  THE SYNTHESIS AND PHARMACOLOGICAL ACTION OF TREMETONE.

Authors:  D M BOWNE; J I DEGRAW; V R SHAH; W A BONNER
Journal:  J Med Chem       Date:  1963-05       Impact factor: 7.446

2.  Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.

Authors:  W Lippmann; T Pugsley; J Merker
Journal:  Life Sci       Date:  1975-01-15       Impact factor: 5.037

3.  Chirality of (+)-octoclothepin, a stereospecific neuroleptic agent.

Authors:  T J Petcher; J Schmutz; H P Weber; T G White
Journal:  Experientia       Date:  1975-12-15

4.  Assessment of antipsychotic activity of an unique agent: SU-23397.

Authors:  E H Mielke; D M Gallant; G Bishop; C M Kessler
Journal:  Psychopharmacol Commun       Date:  1975

5.  A clinical trial of a structurally unique neuroleptic (SU-23397).

Authors:  B M Angrist; G Sathananthan; H Thompson; S Gershon
Journal:  Curr Ther Res Clin Exp       Date:  1975-08

6.  The absolute configuration of the enantiomers of glutethimide and aminoglutethimide.

Authors:  N Finch; R Dziemian; J Cohen; B G Steinetz
Journal:  Experientia       Date:  1975-09-15
  6 in total

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