Literature DB >> 1175729

The absolute configuration of the enantiomers of glutethimide and aminoglutethimide.

N Finch, R Dziemian, J Cohen, B G Steinetz.   

Abstract

Aminoglutethimide (Elipten¿ CIBA) was resolved into the optical antipodes I and II. The endocrinological properties and the absolute configuration of both enantiomers I and II were determined. Most of the steroidal synthesis inhibition was found in the (+) enantiomer II. On the basis of circular dichroism, the R-configuration was assigned to the (+) enantiomer II.

Entities:  

Keywords:  Abortifacient Agents--analysis; Abortion, Drug Induced; Abortion, Induced; Animals, Laboratory; Biology; Clinical Research; Endocrine System; Family Planning; Fertility Control, Postconception; Hormones; Physiology; Progestational Hormones; Progesterone--analysis; Research Methodology

Mesh:

Substances:

Year:  1975        PMID: 1175729     DOI: 10.1007/bf02326922

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  7 in total

1.  The gonadotropin-primed rat: a model for testing agents that influence steroid biosynthesis.

Authors:  O D Sherwood; M L Birkhimer; D G Parkes
Journal:  Endocrinology       Date:  1973-09       Impact factor: 4.736

2.  Successful medical adrenalectomy with amino-glutethimide. Role of altered drug metabolism.

Authors:  R J Santen; A Lipton; J Kendall
Journal:  JAMA       Date:  1974 Dec 23-30       Impact factor: 56.272

3.  Analogs of the abortifacient aminoglutethimide.

Authors:  R Paul; R P Williams; E Cohen
Journal:  J Med Chem       Date:  1974-05       Impact factor: 7.446

4.  Preliminary trial of aminoglutethimide in breast cancer.

Authors:  C T Griffiths; T C Hall; Z Saba; J J Barlow; H B Nevinny
Journal:  Cancer       Date:  1973-07       Impact factor: 6.860

5.  [Configuration of various disubstituted chiralic succinimides].

Authors:  J Knabe; W Koch
Journal:  Arch Pharm (Weinheim)       Date:  1972-11       Impact factor: 3.751

6.  The influence of an anti-steroidogenic drug (aminoglutethimide phosphate) on pregnancy maintenance.

Authors:  S R Glasser; R C Northcutt; F Chytil; C A Strott
Journal:  Endocrinology       Date:  1972-05       Impact factor: 4.736

7.  Effect of aminoglutethimide on serum progesterone and estrogen in the pregnant baboon (Papio SP).

Authors:  B G Steinetz; W H Niemann; T Giannina; D Duncan; J J Chart
Journal:  Proc Soc Exp Biol Med       Date:  1975-03
  7 in total
  2 in total

1.  The absolute configuration of SU 23397: a novel neuroleptic agent.

Authors:  N K Chaudhuri; T J Ball; N Finch
Journal:  Experientia       Date:  1977-05-15

2.  Effects of aminoglutethiumide and its metabolite, N-acetylaminoglutethimide, on bovine adrenocortical and human placental cytochromes P-450scc.

Authors:  J J Sheets; L E Vickery
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-10       Impact factor: 3.000

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.