Literature DB >> 8627597

2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.

J J Hale1, S G Mills, M MacCoss, S K Shah, H Qi, D J Mathre, M A Cascieri, S Sadowski, C D Strader, D E MacIntyre, J M Metzger.   

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Year:  1996        PMID： 8627597     DOI： 10.1021/jm950654w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  4 in total

1.  Heterocycles via intramolecular platinum-catalyzed propargylic substitution.

Authors:  Qiren Liang; Jef K De Brabander
Journal:  Tetrahedron       Date:  2011-07-08       Impact factor: 2.457

2.  Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.

Authors:  Shuanghong Chen; Mengjie Lu; Dongsheng Liu; Lingyun Yang; Cuiying Yi; Limin Ma; Hui Zhang; Qing Liu; Thomas M Frimurer; Ming-Wei Wang; Thue W Schwartz; Raymond C Stevens; Beili Wu; Kurt Wüthrich; Qiang Zhao
Journal:  Nat Commun       Date:  2019-02-07       Impact factor: 14.919

3.  Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors.

Authors:  Paweł K Halik; Piotr F J Lipiński; Joanna Matalińska; Przemysław Koźmiński; Aleksandra Misicka; Ewa Gniazdowska
Journal:  Molecules       Date:  2020-08-18       Impact factor: 4.411

4.  Reactions of glycidyl derivatives with ambident nucleophiles; part 2: amino acid derivatives.

Authors:  Gerald Dyker; Andreas Thöne; Gerald Henkel
Journal:  Beilstein J Org Chem       Date:  2007-09-27       Impact factor: 2.883
  4 in total

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