Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Heterocycles via intramolecular platinum-catalyzed propargylic substitution.

Literature DB >> 21731116

Heterocycles via intramolecular platinum-catalyzed propargylic substitution.

Abstract

We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes and sulfamates with high cis-selectivity.

Entities: CellLine Chemical Disease Gene

Year: 2011 PMID： 21731116 PMCID： PMC3126105 DOI： 10.1016/j.tet.2011.03.115

Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457

32 in total

1. NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.

Authors: Hugo E. Gottlieb; Vadim Kotlyar; Abraham Nudelman
Journal: J Org Chem Date: 1997-10-17 Impact factor: 4.354

2. Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.

Authors: Michael C Chrysselis; Eleni A Rekka; Ioanna C Siskou; Panos N Kourounakis
Journal: J Med Chem Date: 2002-11-21 Impact factor: 7.446

3. Golden carousel in catalysis: the cationic gold/propargylic ester cycle.

Authors: Andrea Correa; Nicolas Marion; Louis Fensterbank; Max Malacria; Steven P Nolan; Luigi Cavallo
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

4. 2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.

Authors: J J Hale; S G Mills; M MacCoss; S K Shah; H Qi; D J Mathre; M A Cascieri; S Sadowski; C D Strader; D E MacIntyre; J M Metzger
Journal: J Med Chem Date: 1996-04-26 Impact factor: 7.446

5. (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake.

Authors: J L Kelley; D L Musso; G E Boswell; F E Soroko; B R Cooper
Journal: J Med Chem Date: 1996-01-19 Impact factor: 7.446

6. Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

Authors: Brett D Allison; Victor K Phuong; Laura C McAtee; Mark Rosen; Magda Morton; Clodagh Prendergast; Terry Barrett; Guy Lagaud; Jamie Freedman; Lina Li; Xiaodong Wu; Hariharan Venkatesan; Marna Pippel; Craig Woods; Michèle C Rizzolio; Michael Hack; Kenway Hoey; Xiaohu Deng; Christopher King; Nigel P Shankley; Michael H Rabinowitz
Journal: J Med Chem Date: 2006-10-19 Impact factor: 7.446

3. Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry.

Authors: Ravi S Loka; Matthew S McConnell; Hien M Nguyen
Journal: Biomacromolecules Date: 2015-12-01 Impact factor: 6.988

3 in total

Heterocycles via intramolecular platinum-catalyzed propargylic substitution.

1. NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.

2. Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.

3. Golden carousel in catalysis: the cationic gold/propargylic ester cycle.

4. 2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.

5. (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake.

6. Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

7. Novel synthesis of cis-3,5-disubstituted morpholine derivatives.

8. Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.

9. (+)-saxitoxin: a first and second generation stereoselective synthesis.

10. Efficient, stereoselective synthesis of trans-2,5-disubstituted morpholines.

Review 1. Scope and advances in the catalytic propargylic substitution reaction.

2. A biosynthetically inspired synthesis of (-)-berkelic acid and analogs.

3. Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry.