| Literature DB >> 8626248 |
J E Leet1, D R Schroeder, J Golik, J A Matson, T W Doyle, K S Lam, S E Hill, M S Lee, J L Whitney, B S Krishnan.
Abstract
The structure of the antitumor antibiotic himastatin was determined using a combination of spectroscopic and chemical degradation techniques. Himastatin is a unique dimeric cyclohexadepsipeptide joined through a biphenyl linkage between two oxidized tryptophan units. The gross structure of the dimer was established through degradative ozonolysis. Himastatin consists of D-valine, D-threonine, L-leucine, L-alpha-hydroxyisovaleric acid, (3R,5R)-5-hydroxypiperazic acid, and (2R,3aR,8aR)-3a-hydroxyhexahydropyrrolo[2,3b]indole 2-carboxylic acid subunits.Entities:
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Year: 1996 PMID： 8626248 DOI： 10.7164/antibiotics.49.299
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649