Literature DB >> 8622901

Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer.

S M Farrington1, C Cunningham, S M Boyle, A H Wyllie, M G Dunlop.   

Abstract

Loss of heterozygosity (LOH) of markers at chromosome 8p is frequently noted in many different tumour types, including colorectal cancer. Numerous investigations indicate the presence of more than tumour suppressor gene (TSG) located on 8p. In this study, we describe a detailed LOH map in colorectal cancer and relate this to physical mapping data from reduced radiation 8p hybrids, yeast artificial chromosome (YAC) co-localisation of markers and fluorescence in situ hybridisation data. These data indicate the presence of two regions harbouring putative TSG's between the polymorphic markers for the LPL gene-D8S298 (approximately 4 Mb) and the markers D8S136-D8S137 (approximately 8 Mb). Yeast Artificial Chromosomes (YAC) have been isolated from these regions of interest to aid the localisation of the putative TSG's.

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Year:  1996        PMID： 8622901

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  8 in total

1.  N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions.

Authors:  A L Hubbard; D J Harrison; C Moyes; A H Wyllie; C Cunningham; E Mannion; C A Smith
Journal:  Gut       Date:  1997-08       Impact factor: 23.059

2.  Expression of arylamine N-acetyltransferase in human intestine.

Authors:  D Hickman; J Pope; S D Patil; G Fakis; V Smelt; L A Stanley; M Payton; J D Unadkat; E Sim
Journal:  Gut       Date:  1998-03       Impact factor: 23.059

Review 3.  DNA copy number losses in human neoplasms.

Authors:  S Knuutila; Y Aalto; K Autio; A M Björkqvist; W El-Rifai; S Hemmer; T Huhta; E Kettunen; S Kiuru-Kuhlefelt; M L Larramendy; T Lushnikova; O Monni; H Pere; J Tapper; M Tarkkanen; A Varis; V M Wasenius; M Wolf; Y Zhu
Journal:  Am J Pathol       Date:  1999-09       Impact factor: 4.307

4.  Allelic imbalance of 8p indicates poor survival in gastric cancer.

Authors:  Amy J French; Gina Petroni; Stephen N Thibideau; Mark Smolkin; Eric Bissonette; Franco Roviello; Jeffrey C Harper; Benjamin R Koch; Sarah A Anderson; Scott J Hebbring; Steven M Powell
Journal:  J Mol Diagn       Date:  2004-08       Impact factor: 5.568

5.  Analysis of DLC-1 expression in human breast cancer.

Authors:  Marlies Plaumann; Susanne Seitz; Renate Frege; Lope Estevez-Schwarz; Siegfried Scherneck
Journal:  J Cancer Res Clin Oncol       Date:  2003-05-21       Impact factor: 4.553

6.  Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis.

Authors:  S Seitz; K Rohde; E Bender; A Nothnagel; H Pidde; O M Ullrich; A El-Zehairy; W Haensch; B Jandrig; K Kölble; P M Schlag; S Scherneck
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

7.  Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma.

Authors:  Ya-Zhen Zhu; Xi-Wen Liao; Wu Yin; Hai-Ming Wei
Journal:  Int J Gen Med       Date:  2022-02-04

8.  High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma.

Authors:  I I Wistuba; A Maitra; R Carrasco; M Tang; P Troncoso; J D Minna; A F Gazdar
Journal:  Br J Cancer       Date:  2002-08-12       Impact factor: 7.640
  8 in total

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