Literature DB >> 15269302

Allelic imbalance of 8p indicates poor survival in gastric cancer.

Amy J French1, Gina Petroni, Stephen N Thibideau, Mark Smolkin, Eric Bissonette, Franco Roviello, Jeffrey C Harper, Benjamin R Koch, Sarah A Anderson, Scott J Hebbring, Steven M Powell.   

Abstract

Gastric cancer is a common tumor worldwide and a tremendous health burden. However, the underlying mechanisms of tumorigenesis in this cancer's development are primarily undefined. Allelic imbalance (AI) of 8p has been reported in many cancers, yet, the target(s) of alteration and the importance of allelic imbalance on this chromosomal arm in gastric carcinoma development remained to be characterized. Our findings confirmed a high rate of AI on 8p in gastric cancers. Moreover, we demonstrated that AI on 8p, either overall or at marker D8S560, was associated with poorer survival in patients with gastric cancer. Finally, gastric cancers with a high rate of microsatellite instability were significantly associated with noncardia tumors and with female gender.

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Year:  2004        PMID： 15269302      PMCID： PMC1867637          DOI： 10.1016/S1525-1578(10)60517-X

Source DB:  PubMed          Journal:  J Mol Diagn        ISSN： 1525-1578            Impact factor:   5.568


  63 in total

1.  Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer.

Authors:  S M Farrington; C Cunningham; S M Boyle; A H Wyllie; M G Dunlop
Journal:  Oncogene       Date:  1996-04-18       Impact factor: 9.867

2.  Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.

Authors:  S Thiagalingam; C Lengauer; F S Leach; M Schutte; S A Hahn; J Overhauser; J K Willson; S Markowitz; S R Hamilton; S E Kern; K W Kinzler; B Vogelstein
Journal:  Nat Genet       Date:  1996-07       Impact factor: 38.330

3.  Allelic imbalance and microsatellite instability in prostatic adenocarcinoma.

Authors:  J M Cunningham; A Shan; M J Wick; S K McDonnell; D J Schaid; D J Tester; J Qian; S Takahashi; R B Jenkins; D G Bostwick; S N Thibodeau
Journal:  Cancer Res       Date:  1996-10-01       Impact factor: 12.701

4.  Allelotype of pancreatic adenocarcinoma using xenograft enrichment.

Authors:  S A Hahn; A B Seymour; A T Hoque; M Schutte; L T da Costa; M S Redston; C Caldas; C L Weinstein; A Fischer; C J Yeo
Journal:  Cancer Res       Date:  1995-10-15       Impact factor: 12.701

5.  DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.

Authors:  S A Hahn; M Schutte; A T Hoque; C A Moskaluk; L T da Costa; E Rozenblum; C L Weinstein; A Fischer; C J Yeo; R H Hruban; S E Kern
Journal:  Science       Date:  1996-01-19       Impact factor: 47.728

6.  Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis.

Authors:  N R dos Santos; R Seruca; M Constância; M Seixas; M Sobrinho-Simões
Journal:  Gastroenterology       Date:  1996-01       Impact factor: 22.682

7.  Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile.

Authors:  R Seruca; N R Santos; L David; M Constância; H Barroca; F Carneiro; M Seixas; P Peltomäki; R Lothe; M Sobrinho-Simões
Journal:  Int J Cancer       Date:  1995-02-20       Impact factor: 7.396

8.  Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3.

Authors:  H Suzuki; M Emi; A Komiya; Y Fujiwara; R Yatani; Y Nakamura; J Shimazaki
Journal:  Genes Chromosomes Cancer       Date:  1995-07       Impact factor: 5.006

9.  A 3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer.

Authors:  Y Fujiwara; H Ohata; M Emi; K Okui; K Koyama; E Tsuchiya; T Nakajima; M Monden; T Mori; A Kurimasa
Journal:  Genes Chromosomes Cancer       Date:  1994-05       Impact factor: 5.006

10.  Loss of heterozygosity in 8p is associated with microinvasion in colorectal carcinoma.

Authors:  P R Kelemen; M L Yaremko; A H Kim; A Montag; F Michelassi; C A Westbrook
Journal:  Genes Chromosomes Cancer       Date:  1994-11       Impact factor: 5.006
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  6 in total

1.  NF-κB and cancer: a paradigm of Yin-Yang.

Authors:  Gutian Xiao; Jing Fu
Journal:  Am J Cancer Res       Date:  2010-12-06       Impact factor: 6.166

Review 2.  Cancer and forensic microsatellites.

Authors:  Karen Page; Eleanor A M Graham
Journal:  Forensic Sci Med Pathol       Date:  2008-02-02       Impact factor: 2.007

3.  Clinicopathological and patient characteristics of early gastric neoplasia endoscopically resected with loss of Mlh1 expression.

Authors:  Shuji Sasaki; Kazuo Yashima; Akihiro Hayashi; Yohei Takeda; Akiko Yasugi; Masaharu Koda; Koichiro Kawaguchi; Kenichi Harada; Hisao Ito; Yoshikazu Murawaki
Journal:  Oncol Lett       Date:  2010-12-30       Impact factor: 2.967

Review 4.  Genetic aspects of gastric cancer instability.

Authors:  Petra Hudler
Journal:  ScientificWorldJournal       Date:  2012-04-19

5.  Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.

Authors:  Sophie Bernichtein; Enrico Petretto; Stacey Jamieson; Anuj Goel; Timothy J Aitman; Jonathan M Mangion; Ilpo T Huhtaniemi
Journal:  Endocrinology       Date:  2007-11-15       Impact factor: 4.736

Review 6.  Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.

Authors:  Ismael Riquelme; Kathleen Saavedra; Jaime A Espinoza; Helga Weber; Patricia García; Bruno Nervi; Marcelo Garrido; Alejandro H Corvalán; Juan Carlos Roa; Carolina Bizama
Journal:  Oncotarget       Date:  2015-09-22
  6 in total

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