Literature DB >> 8617754

Activity of the mitochondrial multiple conductance channel is independent of the adenine nucleotide translocator.

T A Lohret1, R C Murphy, T Drgoñ, K W Kinnally.   

Abstract

The functional relationship between the adenine nucleotide translocator (ANT) and the mitochondrial multiple conductance channel (MCC) was investigated using patch-clamp techniques. MCC activity with the same conductance, ion selectivity, voltage dependence, and peptide sensitivity could be reconstituted from inner membrane fractions derived from mitochondria of ANT-deficient and wild-type Saccharomyces cerevisiae. In addition, the MCC activity of mouse kidney mitoplasts was unaffected by carboxyatractyloside, a known inhibitor of ANT and inducer of a permeability transition. These results suggest that MCC activity is independent of ANT.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8617754     DOI： 10.1074/jbc.271.9.4846

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  18 in total

Review 1.  MCC and PSC, the putative protein import channels of mitochondria.

Authors:  K W Kinnally; C Muro; M L Campo
Journal:  J Bioenerg Biomembr       Date:  2000-02       Impact factor: 2.945

2.  Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes.

Authors:  Concepción Muro; Serguei M Grigoriev; Dawn Pietkiewicz; Kathleen W Kinnally; María Luisa Campo
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

Review 3.  Mitochondrial ion channels: gatekeepers of life and death.

Authors:  Brian O'Rourke; Sonia Cortassa; Miguel A Aon
Journal:  Physiology (Bethesda)       Date:  2005-10

Review 4.  Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore?

Authors:  S Manon; X Roucou; M Guérin; M Rigoulet; B Guérin
Journal:  J Bioenerg Biomembr       Date:  1998-10       Impact factor: 2.945

Review 5.  Mitochondrial channels revisited.

Authors:  C A Mannella
Journal:  J Bioenerg Biomembr       Date:  1996-04       Impact factor: 2.945

Review 6.  Perspectives on the mitochondrial multiple conductance channel.

Authors:  K W Kinnally; T A Lohret; M L Campo; C A Mannella
Journal:  J Bioenerg Biomembr       Date:  1996-04       Impact factor: 2.945

Review 7.  Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acids.

Authors:  María Luisa Campo; Pablo M Peixoto; Sonia Martínez-Caballero
Journal:  J Bioenerg Biomembr       Date:  2016-05-05       Impact factor: 2.945

Review 8.  The mitochondrial permeability transition pore and its role in cell death.

Authors:  M Crompton
Journal:  Biochem J       Date:  1999-07-15       Impact factor: 3.857

Review 9.  ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.

Authors:  Nelli Mnatsakanyan; Elizabeth Ann Jonas
Journal:  J Mol Cell Cardiol       Date:  2020-05-24       Impact factor: 5.000

10.  Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate--DIDS.

Authors:  Zuzana Tomaskova; Jana Gaburjakova; Anna Brezova; Marta Gaburjakova
Journal:  J Bioenerg Biomembr       Date:  2007-09-25       Impact factor: 2.945
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.