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Literature DB >> 32461058

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.

Nelli Mnatsakanyan¹, Elizabeth Ann Jonas².

Abstract

The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.

Entities: CellLine Chemical Disease Gene Species

Keywords: ATP synthase; Apoptosis; Mitochondria; Mitochondrial permeability transition pore

Mesh：

Substances：

Year: 2020 PMID： 32461058 PMCID： PMC7877492 DOI： 10.1016/j.yjmcc.2020.05.013

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

172 in total

Review 1. Coordinating growth and maturation - insights from Drosophila.

Authors: Jason M Tennessen; Carl S Thummel
Journal: Curr Biol Date: 2011-09-27 Impact factor: 10.834

2. The mitochondrial permeability transition pore may comprise VDAC molecules. II. The electrophysiological properties of VDAC are compatible with those of the mitochondrial megachannel.

Authors: I Szabó; V De Pinto; M Zoratti
Journal: FEBS Lett Date: 1993-09-13 Impact factor: 4.124

3. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.

Authors: John G Strumbos; Maile R Brown; Jack Kronengold; Daniel B Polley; Leonard K Kaczmarek
Journal: J Neurosci Date: 2010-08-04 Impact factor: 6.167

4. Altered synaptic plasticity in a mouse model of fragile X mental retardation.

Authors: Kimberly M Huber; Sean M Gallagher; Stephen T Warren; Mark F Bear
Journal: Proc Natl Acad Sci U S A Date: 2002-05-28 Impact factor: 11.205

5. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

Authors: B Chelli; A Falleni; F Salvetti; V Gremigni; A Lucacchini; C Martini
Journal: Biochem Pharmacol Date: 2001-03-15 Impact factor: 5.858

Review 6. Physiological roles of the mitochondrial permeability transition pore.

Authors: Nelli Mnatsakanyan; Gisela Beutner; George A Porter; Kambiz N Alavian; Elizabeth A Jonas
Journal: J Bioenerg Biomembr Date: 2016-02-11 Impact factor: 2.945

7. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.

Authors: Vincenzo Bonifati; Patrizia Rizzu; Marijke J van Baren; Onno Schaap; Guido J Breedveld; Elmar Krieger; Marieke C J Dekker; Ferdinando Squitieri; Pablo Ibanez; Marijke Joosse; Jeroen W van Dongen; Nicola Vanacore; John C van Swieten; Alexis Brice; Giuseppe Meco; Cornelia M van Duijn; Ben A Oostra; Peter Heutink
Journal: Science Date: 2002-11-21 Impact factor: 47.728

8. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

Authors: P Bernardi
Journal: J Biol Chem Date: 1992-05-05 Impact factor: 5.157

Review 9. Mitochondrial medicine for neurodegenerative diseases.

Authors: Heng Du; Shirley ShiDu Yan
Journal: Int J Biochem Cell Biol Date: 2010-01-11 Impact factor: 5.085

10. Unusual features of the c-ring of F₁F_O ATP synthases.

Authors: A V Vlasov; K V Kovalev; S-H Marx; E S Round; I Yu Gushchin; V A Polovinkin; N M Tsoy; I S Okhrimenko; V I Borshchevskiy; G D Büldt; Yu L Ryzhykau; A V Rogachev; V V Chupin; A I Kuklin; N A Dencher; V I Gordeliy
Journal: Sci Rep Date: 2019-12-06 Impact factor: 4.379

12 in total

1. Cyclophilin D regulation of the mitochondrial permeability transition pore.

Authors: Elizabeth Murphy
Journal: Curr Opin Physiol Date: 2022-01-26

Review 2. The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function.

Authors: Sonia Domínguez-Zorita; Inés Romero-Carramiñana; José M Cuezva; Pau B Esparza-Moltó
Journal: Front Physiol Date: 2022-03-18 Impact factor: 4.755

3. Alpha-tocotrienol enhances arborization of primary hippocampal neurons via upregulation of Bcl-xL.

Authors: Han-A Park; Kristi M Crowe-White; Lukasz Ciesla; Madison Scott; Sydni Bannerman; Abigail U Davis; Bishnu Adhikari; Garrett Burnett; Katheryn Broman; Khondoker Adeba Ferdous; Kimberly H Lackey; Pawel Licznerski; Elizabeth A Jonas
Journal: Nutr Res Date: 2022-03-07 Impact factor: 3.876

Review 4. Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.

Authors: Salvatore Nesci; Fabiana Trombetti; Alessandra Pagliarani; Vittoria Ventrella; Cristina Algieri; Gaia Tioli; Giorgio Lenaz
Journal: Life (Basel) Date: 2021-03-15

Review 5. Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.

Authors: M A Neginskaya; E V Pavlov; S-S Sheu
Journal: Biochim Biophys Acta Bioenerg Date: 2020-12-24 Impact factor: 3.991

Review 6. Mitochondrial Cyclosporine A-Independent Palmitate/Ca²⁺-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.

Authors: Galina D Mironova; Evgeny V Pavlov
Journal: Cells Date: 2021-01-11 Impact factor: 6.600

Review 7. Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.

Authors: Faustino Mollinedo; Consuelo Gajate
Journal: Pharmaceutics Date: 2021-05-20 Impact factor: 6.321

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.

Review 1. Coordinating growth and maturation - insights from Drosophila.

2. The mitochondrial permeability transition pore may comprise VDAC molecules. II. The electrophysiological properties of VDAC are compatible with those of the mitochondrial megachannel.

3. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.

4. Altered synaptic plasticity in a mouse model of fragile X mental retardation.

5. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

Review 6. Physiological roles of the mitochondrial permeability transition pore.

7. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.

8. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

Review 9. Mitochondrial medicine for neurodegenerative diseases.

10. Unusual features of the c-ring of F₁F_O ATP synthases.

1. Cyclophilin D regulation of the mitochondrial permeability transition pore.

Review 2. The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function.

3. Alpha-tocotrienol enhances arborization of primary hippocampal neurons via upregulation of Bcl-xL.

Review 4. Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.

Review 5. Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.

Review 6. Mitochondrial Cyclosporine A-Independent Palmitate/Ca²⁺-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.

Review 7. Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.

Review 8. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU_cx.

Review 9. Anti-Apoptotic Effects of Carotenoids in Neurodegeneration.

Review 10. From the Structural and (Dys)Function of ATP Synthase to Deficiency in Age-Related Diseases.

Review 1. Coordinating growth and maturation - insights from Drosophila.

Review 6. Physiological roles of the mitochondrial permeability transition pore.

Review 9. Mitochondrial medicine for neurodegenerative diseases.

Review 2. The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function.

Review 4. Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.

Review 5. Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.

Review 6. Mitochondrial Cyclosporine A-Independent Palmitate/Ca2+-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.

Review 7. Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.

Review 8. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCUcx.

Review 9. Anti-Apoptotic Effects of Carotenoids in Neurodegeneration.

Review 10. From the Structural and (Dys)Function of ATP Synthase to Deficiency in Age-Related Diseases.

Review 6. Mitochondrial Cyclosporine A-Independent Palmitate/Ca²⁺-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.

Review 8. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU_cx.