| Literature DB >> 8616783 |
L Michaux1, I Wlodarska, E R Vellosa, G Verhoef, A Van Orshoven, J L Michaux, J M Scheiff, C Mecucci, H Van den Berghe.
Abstract
Translocation (Y;1)(q12;q12) is a rare cytogenetic anomaly occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.Entities:
Mesh：
Year: 1996 PMID： 8616783 DOI： 10.1016/0165-4608(95)00141-7
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608