Literature DB >> 861200

Mechanism of 25-hydroxyvitamin D3 24-hydroxylation: incorporation of oxygen-18 into the 24 position of 25-hydroxyvitamin D3.

T C Madhok, H K Schnoes, H F DeLuca.   

Abstract

The oxygen enzymatically inserted as a hydroxyl function by chick kidney homogenate into the 24 position of 25-hydroxyvitamin D3 to give 24,25-dihydroxyvitamin D3 is derived exclusively from 18O2. Therefore, like the 25-hydroxyvitamin D3-lalpha-hydroxylase system, the 25-hydroxyvitamin D3-24-hydroxylase system is also a monooxygenase ("mixed-function oxidase").

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Year:  1977        PMID： 861200     DOI： 10.1021/bi00629a015

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  5 in total

1.  Incorportion of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase.

Authors:  T C Madhok; H K Schnoes; H F DeLuca
Journal:  Biochem J       Date:  1978-11-01       Impact factor: 3.857

Review 2.  Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment.

Authors:  Peter J Tebben; Ravinder J Singh; Rajiv Kumar
Journal:  Endocr Rev       Date:  2016-09-02       Impact factor: 19.871

3.  Solubilization and reconstitution of kidney 25-hydroxyvitamin D3 1 alpha- and 24-hydroxylases from vitamin D-replete pigs.

Authors:  R W Gray; J G Ghazarian
Journal:  Biochem J       Date:  1989-04-15       Impact factor: 3.857

4.  Reciprocal post-translational regulation of renal 1 alpha- and 24-hydroxylases of 25-hydroxyvitamin D3 by phosphorylation of ferredoxin. mRNA-directed cell-free synthesis and immunoisolation of ferredoxin.

Authors:  M L Mandel; B Moorthy; J G Ghazarian
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

5.  Fundamental Role of Methylenetetrahydrofolate Reductase 677 C → T Genotype and Flavin Compounds in Biochemical Phenotypes for Schizophrenia and Schizoaffective Psychosis.

Authors:  Stephanie Fryar-Williams
Journal:  Front Psychiatry       Date:  2016-11-09       Impact factor: 4.157
  5 in total

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