| Literature DB >> 8610010 |
S Tan1, Y Hunziker, D F Sargent, T J Richmond.
Abstract
The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.Entities:
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Year: 1996 PMID： 8610010 DOI： 10.1038/381127a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962