Literature DB >> 8609085

Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.

Y Enomoto1, K Shiomi, M Hayashi, R Masuma, T Kawakubo, K Tomosawa, Y Iwai, S Omura.   

Abstract

A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 microM, respectively.

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Year:  1996        PMID： 8609085     DOI： 10.7164/antibiotics.49.50

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Concise Total Synthesis of Herqulines B and C.

Authors:  Chi He; Thomas P Stratton; Phil S Baran
Journal:  J Am Chem Soc       Date:  2018-12-24       Impact factor: 15.419

Review 2.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

3.  Ideality in Context: Motivations for Total Synthesis.

Authors:  David S Peters; Cody Ross Pitts; Kyle S McClymont; Thomas P Stratton; Cheng Bi; Phil S Baran
Journal:  Acc Chem Res       Date:  2021-01-21       Impact factor: 22.384

4.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

5.  Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A.

Authors:  Xia Yu; Fang Liu; Yi Zou; Man-Cheng Tang; Leibniz Hang; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2016-10-06       Impact factor: 15.419

6.  Co-Culture of Plant Beneficial Microbes as Source of Bioactive Metabolites.

Authors:  F Vinale; R Nicoletti; F Borrelli; A Mangoni; O A Parisi; R Marra; N Lombardi; F Lacatena; L Grauso; S Finizio; M Lorito; S L Woo
Journal:  Sci Rep       Date:  2017-10-30       Impact factor: 4.379

7.  Diketoacetonylphenalenone, Derived from Hawaiian Volcanic Soil-Associated Fungus Penicillium herquei FT729, Regulates T Cell Activation via Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathway.

Authors:  Hyun-Su Lee; Jae Sik Yu; Ki Hyun Kim; Gil-Saeng Jeong
Journal:  Molecules       Date:  2020-11-17       Impact factor: 4.411
  7 in total

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