Literature DB >> 8608234

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse.

L Yaswen1, A B Kulkarni, T Fredrickson, B Mittleman, R Schiffman, S Payne, G Longenecker, E Mozes, S Karlsson.   

Abstract

Targeted disruption of the transforming growth factor-beta 1 (TGF-beta 1) gene in mice results in the development of a massive multifocal inflammatory disease in many tissues. Because no detectable pathogen was identified, we examined whether autoimmune mechanisms played a role in initiating or maintaining the inflammatory disease. The serum of TGF-beta 1 knockout mice contained elevated titers of antibodies to nuclear antigens (ssDNA, dsDNA, Sm, and RNP) as well as reactivity against the 16/6 idiotype (16/6 Id). In addition, Ig deposits were detected in renal glomeruli of TGF- beta 1 knockout mice. Transplantation of TGF-beta 1 knockout hematopoietic cells into normal irradiated recipients resulted in a similar profile of autoantibody production as well as in the induction of inflammatory lesions. Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent.

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Year:  1996        PMID： 8608234

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  53 in total

1.  Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies.

Authors:  K Nagaraju; N Raben; L Loeffler; T Parker; P J Rochon; E Lee; C Danning; R Wada; C Thompson; G Bahtiyar; J Craft; R Hooft Van Huijsduijnen; P Plotz
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

Review 2.  Cardiac fibrosis: potential therapeutic targets.

Authors:  Shuin Park; Ngoc B Nguyen; Arash Pezhouman; Reza Ardehali
Journal:  Transl Res       Date:  2019-03-09       Impact factor: 7.012

3.  TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues.

Authors:  T Nakabayashi; K M Sakata; A Sakata; L Kong; C A Lau; J J Letterio; N Vela-Roch; N Talal; H Dang
Journal:  Inflammation       Date:  2001-04       Impact factor: 4.092

4.  Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

Authors:  J J Letterio; A G Geiser; A B Kulkarni; H Dang; L Kong; T Nakabayashi; C L Mackall; R E Gress; A B Roberts
Journal:  J Clin Invest       Date:  1996-11-01       Impact factor: 14.808

5.  Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis.

Authors:  Kensuke Sasaki; Shigehiro Doi; Ayumu Nakashima; Taisuke Irifuku; Kyoko Yamada; Keiko Kokoroishi; Toshinori Ueno; Toshiki Doi; Eisuke Hida; Koji Arihiro; Nobuoki Kohno; Takao Masaki
Journal:  J Am Soc Nephrol       Date:  2015-06-04       Impact factor: 10.121

6.  Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis.

Authors:  L Ten Klooster; C H M van Moorsel; J M Kwakkel-van Erp; H van Velzen-Blad; J C Grutters
Journal:  Clin Exp Immunol       Date:  2015-06-08       Impact factor: 4.330

Review 7.  Immunoregulation by members of the TGFβ superfamily.

Authors:  WanJun Chen; Peter Ten Dijke
Journal:  Nat Rev Immunol       Date:  2016-11-25       Impact factor: 53.106

8.  The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus.

Authors:  E Eilat; M Dayan; H Zinger; E Mozes
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

9.  Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease.

Authors:  John F Alcorn; Lisa M Rinaldi; Elizabeth F Jaffe; Mirjam van Loon; Jason H T Bates; Yvonne M W Janssen-Heininger; Charles G Irvin
Journal:  Am J Respir Crit Care Med       Date:  2007-08-29       Impact factor: 21.405

10.  Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.

Authors:  Gianluca Turcatel; Katelyn Millette; Matthew Thornton; Stephanie Leguizamon; Brendan Grubbs; Wei Shi; David Warburton
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2016-12-09       Impact factor: 5.464
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