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Literature DB >> 11321361

TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues.

T Nakabayashi¹, K M Sakata, A Sakata, L Kong, C A Lau, J J Letterio, N Vela-Roch, N Talal, H Dang.

Abstract

The TGF-beta1(-/-) mouse is a murine model for systemic autoimmune disease. The aim of this study is to elucidate the immunological mechanism that leads to multifocal tissue inflammation and autoantibody production in TGF-beta1(-/-) mice. Heart, lung, liver, and salivary gland from TGF-beta1(-/-) were assessed for CD154 expression by RT-PCR and immunohistochemistry. Compared to wild-type littermates, CD154 expression was elevated in all tissues studied. Furthermore, IL-12 mRNA was expressed in the salivary gland and heart of TGF-beta1(-/-) mice and not in wild-type littermates. This suggests that the CD154 pathway is activated in these tissues. This shows that TGF-beta1 regulates CD154 expression leading to spontaneous IL-12 production and autoimmunity.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11321361 DOI： 10.1023/a:1007158219974

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

27 in total

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Authors: M Koshy; D Berger; M K Crow
Journal: J Clin Invest Date: 1996-08-01 Impact factor: 14.808

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Journal: J Clin Invest Date: 1996-05-01 Impact factor: 14.808

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Authors: J Ma; J Xu; M P Madaio; Q Peng; J Zhang; I S Grewal; R A Flavell; J Craft
Journal: J Immunol Date: 1996-07-01 Impact factor: 5.422

1. The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.

Authors: Marilena Vered; Osnat Grinstein-Koren; Shoshana Reiter; Irit Allon; Dan Dayan
Journal: Int J Exp Pathol Date: 2010-03-26 Impact factor: 1.925

1 in total

TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues.

1. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.

Review 2. CD40-CD40 ligand interaction in autoimmune disease.

Review 3. The taming of IL-12: suppressing the production of proinflammatory cytokines.

4. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.

5. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.

6. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse.

7. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

8. SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

9. Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.

10. Expression of functional CD40 by vascular endothelial cells.

1. The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.