Literature DB >> 8607878

Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland.

R Baler1, S Coon, D C Klein.   

Abstract

The nuclear orphan receptor RZRbeta is highly expressed in the rat pineal gland. Recent studies proposed that melatonin, the pineal hormone which regulates a wide variety of circadian-linked phenomena, may be the natural ligand of this receptor. These provocative reports prompted us to learn more about RZRbeta and how it might function in circadian physiology. Here we confirm high expression of this receptor in the pineal gland, and report that pineal RZRbeta expression exhibits a strong daily rhythm. Expression is under photoneural regulation and involves an adrenergic --> cAMP mechanism.

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Year:  1996        PMID： 8607878     DOI： 10.1006/bbrc.1996.0517

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

Review 1.  Pineal function: impact of microarray analysis.

Authors:  David C Klein; Michael J Bailey; David A Carter; Jong-so Kim; Qiong Shi; Anthony K Ho; Constance L Chik; Pascaline Gaildrat; Fabrice Morin; Surajit Ganguly; Martin F Rath; Morten Møller; David Sugden; Zoila G Rangel; Peter J Munson; Joan L Weller; Steven L Coon
Journal:  Mol Cell Endocrinol       Date:  2009-07-19       Impact factor: 4.102

Review 2.  Molecular mechanisms of melatonin's inhibitory actions on breast cancers.

Authors:  Sara Proietti; Alessandra Cucina; Russel J Reiter; Mariano Bizzarri
Journal:  Cell Mol Life Sci       Date:  2012-09-25       Impact factor: 9.261

3.  Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Authors:  Michael J Bailey; Steven L Coon; David A Carter; Ann Humphries; Jong-So Kim; Qiong Shi; Pascaline Gaildrat; Fabrice Morin; Surajit Ganguly; John B Hogenesch; Joan L Weller; Martin F Rath; Morten Møller; Ruben Baler; David Sugden; Zoila G Rangel; Peter J Munson; David C Klein
Journal:  J Biol Chem       Date:  2008-12-22       Impact factor: 5.157

4.  Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.

Authors:  E André; F Conquet; M Steinmayr; S C Stratton; V Porciatti; M Becker-André
Journal:  EMBO J       Date:  1998-07-15       Impact factor: 11.598

5.  Rhythmic Diurnal Synthesis and Signaling of Retinoic Acid in the Rat Pineal Gland and Its Action to Rapidly Downregulate ERK Phosphorylation.

Authors:  Anna Ashton; Patrick N Stoney; Jemma Ransom; Peter McCaffery
Journal:  Mol Neurobiol       Date:  2018-03-08       Impact factor: 5.590
  5 in total

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