Literature DB >> 8607272

Mutational analysis of interactions between the Gag precursor proteins of murine leukemia viruses.

K Alin1, S P Goff.   

Abstract

The yeast two-hybrid system was used to test for interactions among the Gag precursor proteins of three members of the murine leukemia virus family. These Gag proteins all interact with each other in all combinations, but do not interact with the distantly related HIV-1 Gag. A series of deletion mutants of Moloney MuLV were examined to determine the minimal interaction domain. Either one of two regions of Gag was independently sufficient to mediate homodimerization, suggesting multiple points of contact in the precursor. Analysis of a set of point mutations in the CA region revealed a complex pattern of effects on Gag-Gag interactions.

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Year:  1996        PMID： 8607272     DOI： 10.1006/viro.1996.0078

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  21 in total

1.  Identification of residues of the Moloney murine leukemia virus nucleocapsid critical for viral DNA synthesis in vivo.

Authors:  J Gonsky; E Bacharach; S P Goff
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

2.  Intracellular targeting of Gag proteins of the Drosophila telomeric retrotransposons.

Authors:  S Rashkova; A Athanasiadis; M-L Pardue
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

3.  A long terminal repeat-containing retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like particles which mediate reverse transcription.

Authors:  Laure Teysset; Van-Dinh Dang; Min Kyung Kim; Henry L Levin
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

4.  Basic residues of the retroviral nucleocapsid play different roles in gag-gag and Gag-Psi RNA interactions.

Authors:  Eun-Gyung Lee; Maxine L Linial
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

5.  Effects of Gag mutation and processing on retroviral dimeric RNA maturation.

Authors:  William Fu; Que Dang; Kunio Nagashima; Eric O Freed; Vinay K Pathak; Wei-Shau Hu
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

6.  A new retroelement constituted by a natural alternatively spliced RNA of murine replication-competent retroviruses.

Authors:  Laurent Houzet; Jean Luc Battini; Eric Bernard; Valerie Thibert; Marylène Mougel
Journal:  EMBO J       Date:  2003-09-15       Impact factor: 11.598

7.  Genetic analysis of interactions between Gag proteins of Rous sarcoma virus.

Authors:  X Li; B Yuan; S P Goff
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

8.  Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.

Authors:  Q K Zhang; S Boast; K de los Santos; M Begemann; S P Goff
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

9.  Murine leukemia virus particle assembly quantitated by fluorescence microscopy: role of Gag-Gag interactions and membrane association.

Authors:  Mariam Andrawiss; Yasuhiro Takeuchi; Lindsay Hewlett; Mary Collins
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  Intracellular targeting of telomeric retrotransposon Gag proteins of distantly related Drosophila species.

Authors:  Elena Casacuberta; Fernando Azorín Marín; Mary-Lou Pardue
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-04       Impact factor: 11.205
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