Literature DB >> 8606117

Human pro- and anti-inflammatory cytokine patterns induced by Streptococcus pyogenes erythrogenic (pyrogenic) exotoxin A and C superantigens.

H Müller-Alouf1, J E Alouf, D Gerlach, J H Ozegowski, C Fitting, J M Cavaillon.   

Abstract

The superantigenic streptococcal erythrogenic toxins A and C (ETA/SPEA and ETC/SPEC) elicit the production by human peripheral blood mononuclear cells of substantial amounts of Th1-derived cytokines (interleukin-2 [IL-2] and gamma interferon) as well as anti-inflammatory cytokines (IL-10 and IL-1 receptor antagonist). In contrast, very low levels of IL-4 and no alpha interferon were induced. The production of these cytokines after stimulation with Streptococcus pyogenes heat-killed bacteria and lipopolysaccharide from gram negative bacteria differed qualitatively and quantitatively from that elicited by the superantigens.

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Year:  1996        PMID： 8606117      PMCID： PMC173942          DOI： 10.1128/iai.64.4.1450-1453.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

Review 1.  Bacterial toxin-induced cytokine production studied at the single-cell level.

Authors:  J Andersson; S Nagy; L Björk; J Abrams; S Holm; U Andersson
Journal:  Immunol Rev       Date:  1992-06       Impact factor: 12.988

Review 2.  T-cell activation by superantigens.

Authors:  S R Webb; N R Gascoigne
Journal:  Curr Opin Immunol       Date:  1994-06       Impact factor: 7.486

Review 3.  Role of cytokines in determining T-lymphocyte function.

Authors:  A O'Garra; K Murphy
Journal:  Curr Opin Immunol       Date:  1994-06       Impact factor: 7.486

Review 4.  Superantigen mediated shock: a cytokine release syndrome.

Authors:  T Miethke; C Wahl; D Regele; H Gaus; K Heeg; H Wagner
Journal:  Immunobiology       Date:  1993-11       Impact factor: 3.144

5.  Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells.

Authors:  M J Aman; G Rudolf; J Goldschmitt; W E Aulitzky; C Lam; C Huber; C Peschel
Journal:  Blood       Date:  1993-10-15       Impact factor: 22.113

6.  Enhancement of polymorphonuclear leukocyte (PMN) function by OK-432.

Authors:  E Ueta; M Umazume; T Yamamoto; T Osaki
Journal:  Int J Immunopharmacol       Date:  1994-01

7.  Streptococcal erythrogenic toxin type C is not a phosphorylated protein. Description of two different purification procedures and investigation of its phosphorylation state.

Authors:  J H Ozegowski; L Wollweber; K H Schmidt; S Vettermann; W Reichardt; W Köhler
Journal:  FEMS Immunol Med Microbiol       Date:  1994-06

8.  Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

Authors:  G Del Prete; M De Carli; F Almerigogna; M G Giudizi; R Biagiotti; S Romagnani
Journal:  J Immunol       Date:  1993-01-15       Impact factor: 5.422

9.  Similar cytokine induction profiles of a novel streptococcal exotoxin, MF, and pyrogenic exotoxins A and B.

Authors:  A Norrby-Teglund; M Norgren; S E Holm; U Andersson; J Andersson
Journal:  Infect Immun       Date:  1994-09       Impact factor: 3.441

10.  Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis.

Authors:  S P Hackett; D L Stevens
Journal:  J Infect Dis       Date:  1993-07       Impact factor: 5.226
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  3 in total

1.  Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A.

Authors:  H Müller-Alouf; T Proft; T M Zollner; D Gerlach; E Champagne; P Desreumaux; C Fitting; C Geoffroy-Fauvet; J E Alouf; J M Cavaillon
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

2.  Inhibition of interleukin-2 by a Gram-positive bacterium, Streptococcus mutans.

Authors:  L M Plitnick; J A Banas; D M Jelley-Gibbs; J O'neil; T Christian; S P Mudzinski; E J Gosselin
Journal:  Immunology       Date:  1998-12       Impact factor: 7.397

3.  Lipoteichoic acid inhibits interleukin-2 (IL-2) function by direct binding to IL-2.

Authors:  L M Plitnick; R A Jordan; J A Banas; D M Jelley-Gibbs; M C Walsh; M T Preissler; E J Gosselin
Journal:  Clin Diagn Lab Immunol       Date:  2001-09
  3 in total

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