Literature DB >> 8602259

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.

L O Essen1, O Perisic, R Cheung, M Katan, R L Williams.   

Abstract

Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. The structure suggests a mechanism for membrane attachment and Ca2+-dependent hydrolysis of second-messenger precursors. The regulation and reversible membrane association of PI-PLC may serve as a model for understanding other multidomain enzymes involved in phospholipid signalling.

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Year:  1996        PMID： 8602259     DOI： 10.1038/380595a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  113 in total

1.  A lobster phospholipase C-beta that associates with G-proteins in response to odorants.

Authors:  F Xu; T S McClintock
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Role of lipid packing in the activity of phospholipase C-delta1 as determined by hydrostatic pressure measurements.

Authors:  M Rebecchi; M Bon Homme; S Scarlata
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

Review 3.  Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.

Authors:  H LeVine
Journal:  Mol Neurobiol       Date:  1999-04       Impact factor: 5.590

4.  Roles of calcium ions in the membrane binding of C2 domains.

Authors:  R V Stahelin; W Cho
Journal:  Biochem J       Date:  2001-11-01       Impact factor: 3.857

5.  Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.

Authors:  B J Irvin; B L Williams; A E Nilson; H O Maynor; R T Abraham
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

Review 6.  The phospholipase C isozymes and their regulation.

Authors:  Aurelie Gresset; John Sondek; T Kendall Harden
Journal:  Subcell Biochem       Date:  2012

7.  Phospholipase Cdelta1 is required for skin stem cell lineage commitment.

Authors:  Yoshikazu Nakamura; Kiyoko Fukami; Haiyan Yu; Kei Takenaka; Yuki Kataoka; Yuji Shirakata; Shin-Ichi Nishikawa; Koji Hashimoto; Nobuaki Yoshida; Tadaomi Takenawa
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

8.  Whole exome sequencing identifies a novel dominant missense mutation underlying leukonychia in a Pakistani family.

Authors:  Teka Khan; Manan Khan; Ayesha Yousaf; Saadullah Khan; Muhammad Naeem; Akram Shah; Ghulam Murtaza; Asim Ali; Nazish Jabeen; Hafiz Muhammad Jafar Hussain; Hui Ma; Yuanwei Zhang; Muhammad Zubair; Xiaohua Jiang; Huan Zhang
Journal:  J Hum Genet       Date:  2018-07-23       Impact factor: 3.172

9.  C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state.

Authors:  Susy C Kohout; Senena Corbalán-García; Alejandro Torrecillas; Juan C Goméz-Fernandéz; Joseph J Falke
Journal:  Biochemistry       Date:  2002-09-24       Impact factor: 3.162

10.  Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

Authors:  Motohiro Nishida; Kenji Sugimoto; Yuji Hara; Emiko Mori; Takashi Morii; Tomohiro Kurosaki; Yasuo Mori
Journal:  EMBO J       Date:  2003-09-15       Impact factor: 11.598
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