Literature DB >> 8599933

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.

T Yamatsuji1, T Okamoto, S Takeda, Y Murayama, N Tanaka, I Nishimoto.   

Abstract

APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that expression of these mutants (FAD-APPs) causes a clone of COS cells to undergo apoptosis associated with DNA fragmentation. Apoptosis by the three FAD-APPs was the highest among all possible V642 mutants; normal APP695 had no effect on apoptosis, suggesting that apoptosis by APP mutants in this system is phenotypically linked to the FAD trait. FAD-APP-induced apoptosis was sensitive to bcl-2 and most probably mediated by heteromeric G proteins. This study presents a model system allowing analysis of the mechanism for FAD-APP-induced cytotoxicity.

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Year:  1996        PMID： 8599933      PMCID： PMC449968     

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  56 in total

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Journal:  Neuron       Date:  1989-07       Impact factor: 17.173

2.  Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate.

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Journal:  Biochem Biophys Res Commun       Date:  1991-03-15       Impact factor: 3.575

3.  G0 is a major growth cone protein subject to regulation by GAP-43.

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Journal:  Nature       Date:  1990-04-26       Impact factor: 49.962

4.  Developmental expression of Go in neuronal cultures from rat mesencephalon and hypothalamus.

Authors:  J G Granneman; G Kapatos
Journal:  J Neurochem       Date:  1990-06       Impact factor: 5.372

5.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

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Journal:  Nature       Date:  1991-02-21       Impact factor: 49.962

6.  Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid beta-protein precursor involved?

Authors:  K Uéda; G Cole; M Sundsmo; R Katzman; T Saitoh
Journal:  Ann Neurol       Date:  1989-03       Impact factor: 10.422

7.  Molecular cloning and sequence determination of a cDNA coding for the alpha-subunit of a Go-type protein of Xenopus laevis oocytes.

Authors:  J Olate; H Jorquera; P Purcell; J Codina; L Birnbaumer; J E Allende
Journal:  FEBS Lett       Date:  1989-02-13       Impact factor: 4.124

8.  Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.

Authors:  T Van Huynh; G Cole; R Katzman; K P Huang; T Saitoh
Journal:  Arch Neurol       Date:  1989-11

9.  A Go-like protein in Drosophila melanogaster and its expression in memory mutants.

Authors:  A Guillén; J M Jallon; J A Fehrentz; C Pantaloni; J Bockaert; V Homburger
Journal:  EMBO J       Date:  1990-05       Impact factor: 11.598

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

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Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962
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  23 in total

Review 1.  Genetic risk factors in Alzheimer's disease.

Authors:  L Tilley; K Morgan; N Kalsheker
Journal:  Mol Pathol       Date:  1998-12

Review 2.  Molecular mechanisms of go signaling.

Authors:  Meisheng Jiang; Neil S Bajpayee
Journal:  Neurosignals       Date:  2009-02-12

Review 3.  Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.

Authors:  Philip F Copenhaver; Donat Kögel
Journal:  Front Mol Neurosci       Date:  2017-01-31       Impact factor: 5.639

Review 4.  Detection of actin cleavage in Alzheimer's disease.

Authors:  A LeBlanc
Journal:  Am J Pathol       Date:  1998-02       Impact factor: 4.307

5.  Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.

Authors:  H M Ellerby; S J Martin; L M Ellerby; S S Naiem; S Rabizadeh; G S Salvesen; C A Casiano; N R Cashman; D R Green; D E Bredesen
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

6.  Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.

Authors:  T Niikura; Y Hashimoto; T Okamoto; Y Abe; T Yasukawa; M Kawasumi; T Hiraki; Y Kita; K Terashita; K Kouyama; I Nishimoto
Journal:  J Neurosci       Date:  2001-03-15       Impact factor: 6.167

7.  G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

Authors:  U Giambarella; T Yamatsuji; T Okamoto; T Matsui; T Ikezu; Y Murayama; M A Levine; A Katz; N Gautam; I Nishimoto
Journal:  EMBO J       Date:  1997-08-15       Impact factor: 11.598

8.  Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons.

Authors:  E Paradis; H Douillard; M Koutroumanis; C Goodyer; A LeBlanc
Journal:  J Neurosci       Date:  1996-12-01       Impact factor: 6.167

9.  Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

Authors:  S Bursztajn; R DeSouza; D L McPhie; S A Berman; J Shioi; N K Robakis; R L Neve
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

Review 10.  Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease.

Authors:  Elena Anahi Bignante; Florencia Heredia; Gerardo Morfini; Alfredo Lorenzo
Journal:  Neurobiol Aging       Date:  2013-05-25       Impact factor: 4.673
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