Literature DB >> 8596629

The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution.

T Kawashima1, C Berthet-Colominas, M Wulff, S Cusack, R Leberman.   

Abstract

The crystal structure of the EF-Tu.EF-Ts complex from Escherichia coli has been determined to a resolution of 2.5 A. The complex contains two subunits of each of the elongation factors. The two EF-Ts molecules form a tight dimer, but there is little contact between the two EF-Tu molecules. The interaction of EF-Ts with EF-Tu results principally in the disruption of the Mg2+ ion binding site, thereby reducing the affinity of EF-Tu for guanine nucleotides.

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Year:  1996        PMID： 8596629     DOI： 10.1038/379511a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  79 in total

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