Literature DB >> 859659

Mediation of hyperthermia by prostaglandin E2: a new hypothesis.

J A Splawinski.   

Abstract

In rat hypothalamus prostaglandin (PG) E2, unlike PGF2 or arachidonic acid shared the site of hyperthermic action with E. coli endotoxin. The in vitro catabolism of PGE2 in the hypothalami of endotoxin-treated rats was significantly suppressed. It is proposed that endotoxin fever in rats is due to the inhibition of PGE2 breakdown in the hypothalamus.

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Year:  1977        PMID： 859659     DOI： 10.1007/BF00587791

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  8 in total

1.  Evidence that brain prostaglandin synthesis is not essential in fever.

Authors:  W I Cranston; G W Duff; R F Hellon; D Mitchell; Y Townsend
Journal:  J Physiol       Date:  1976-07       Impact factor: 5.182

2.  Modern views on the pathogenesis of fever and the mode of action of antipyretic drugs.

Authors:  A S Milton
Journal:  J Pharm Pharmacol       Date:  1976-04       Impact factor: 3.765

3.  Properties of 15-hydroxy prostaglandin dehydrogenase: structural requirements for substrate binding.

Authors:  M A Marrazzi; F M Matschinsky
Journal:  Prostaglandins       Date:  1972-05

4.  Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro.

Authors:  H S Hansen
Journal:  Prostaglandins       Date:  1974-10-25

5.  Hyperthermic effect of intraventricular injections of arachidonic acid and prostaglandin E2 in the rat.

Authors:  J A Splawiński; K Reichenberg; J Vetulani; J Marchaj; J Kaluza
Journal:  Pol J Pharmacol Pharm       Date:  1974 Jan-Apr

6.  Metabolic degradation of prostaglandin E1 in the lung and kidney of rats in endotoxin shock.

Authors:  J Nakano; A V Prancan
Journal:  Proc Soc Exp Biol Med       Date:  1973-11

7.  Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.

Authors:  S C Lee; L Levine
Journal:  J Biol Chem       Date:  1975-01-25       Impact factor: 5.157

8.  Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat.

Authors:  W G Clark; H R Cumby
Journal:  J Physiol       Date:  1976-06       Impact factor: 5.182
  8 in total
  1 in total

1.  The antipyretic effect of UP 517-03 in the rabbit.

Authors:  F Hertz; M M Chevrier; G Dumeur; J M Lwoff
Journal:  Agents Actions       Date:  1979-12
  1 in total

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