Literature DB >> 317572

The antipyretic effect of UP 517-03 in the rabbit.

F Hertz, M M Chevrier, G Dumeur, J M Lwoff.   

Abstract

The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comparison with acetylsalicylic acid and indomethacin is given. UP 517-03 does not modify the temperature of normothermic rabbits. These results suggests that the antipyretic action of UP 517-03 can be explained by an effect of this substance on the metabolism of arachidonic acid in brain.

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Year:  1979        PMID： 317572     DOI： 10.1007/bf01968121

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

1.  Evidence that brain prostaglandin synthesis is not essential in fever.

Authors:  W I Cranston; G W Duff; R F Hellon; D Mitchell; Y Townsend
Journal:  J Physiol       Date:  1976-07       Impact factor: 5.182

2.  Modern views on the pathogenesis of fever and the mode of action of antipyretic drugs.

Authors:  A S Milton
Journal:  J Pharm Pharmacol       Date:  1976-04       Impact factor: 3.765

3.  Proceedings: Prostaglandin E levels in cerebrospinal fluid of rabbits and the effects of bacterial pyrogen and antipyretic drugs.

Authors:  C A Harvey; A S Milton; D W Straughan
Journal:  J Physiol       Date:  1975-06       Impact factor: 5.182

4.  Effects of prostaglandin E 2 on the body temperature of conscious rats and cats.

Authors:  W J Potts; P F East
Journal:  Arch Int Pharmacodyn Ther       Date:  1972-05

5.  Antiinflammatory and analgesic diastereoisomeric derivatives of indan-5-acetic acid.

Authors:  J M Teulon; J C Cognacq; F Hertz; J M Lwoff; M Foulon; F Baert; M J Brienne; L Lacombe; J Jacques
Journal:  J Med Chem       Date:  1978-09       Impact factor: 7.446

6.  Drugs which inhibit prostaglandin biosynthesis.

Authors:  R J Flower
Journal:  Pharmacol Rev       Date:  1974-03       Impact factor: 25.468

7.  A primate model for the study of human fever.

Authors:  M Perlow; C A Dinarello; S M Wolff
Journal:  J Infect Dis       Date:  1975-08       Impact factor: 5.226

8.  The antipyretic effect of flurbiprofen.

Authors:  A S Van Miert; C T Van Duin
Journal:  Eur J Pharmacol       Date:  1977-08-01       Impact factor: 4.432

9.  Fever produced by prostaglandin E1.

Authors:  W Feldberg; P N Saxena
Journal:  J Physiol       Date:  1971-09       Impact factor: 5.182

10.  Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits.

Authors:  A S Milton; S Wendlandt
Journal:  J Physiol       Date:  1971-10       Impact factor: 5.182
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