Literature DB >> 859658

Prostaglandin and thromboxane biosynthesis inhibitors.

R J Gryglewski.   

Abstract

All acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation. A non-acidic anti-inflammatory agent, 1'-(isopropyl-2-indolyl)-3-pyridyl-3-ketone (L 8027), selectively inhibits biosynthesis of thromboxane A2 in blood platelets and in lungs.

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Year:  1977        PMID： 859658     DOI： 10.1007/BF00587789

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  Inhibition of human platelet aggregation by oral administration of nicergoline. A double-blind study.

Authors:  E Pogliani; A D Volpe; R Ferrari; P Recalcati; C Praga
Journal:  Farmaco Prat       Date:  1975-12

2.  THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.

Authors:  J R VANE
Journal:  Br J Pharmacol Chemother       Date:  1964-10

3.  The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].

Authors:  S Bunting; S Moncada; J R Vane
Journal:  Br J Pharmacol       Date:  1976-07       Impact factor: 8.739

4.  Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.

Authors:  P Needleman; S Moncada; S Bunting; J R Vane; M Hamberg; B Samuelsson
Journal:  Nature       Date:  1976-06-17       Impact factor: 49.962

5.  Thromboxanes: selective biosynthesis and distinct biological properties.

Authors:  P Needleman; M Minkes; A Raz
Journal:  Science       Date:  1976-07-09       Impact factor: 47.728

6.  [In vitro inhibition of the biosynthesis of E 2 prostaglandin by anti-inflammatory drugs].

Authors:  C Deby; M Descamps; F Binon; Z M Bacq
Journal:  C R Seances Soc Biol Fil       Date:  1971

7.  Prostaglandins released by the spleen.

Authors:  N Gilmore; J R Vane; J H Wyllie
Journal:  Nature       Date:  1968-06-22       Impact factor: 49.962

8.  The influence of saturated fatty acids on prostaglandin synthetase activity.

Authors:  J Robak; A Dembińska-Kieć; R Gryglewski
Journal:  Biochem Pharmacol       Date:  1975-11-15       Impact factor: 5.858

9.  Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Authors:  M Hamberg; J Svensson; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205
  9 in total
  5 in total

1.  Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs.

Authors:  L Sterin-Borda; E Borda; E J del Castillo; M F Gimeno; A L Gimeno
Journal:  Experientia       Date:  1982-07-15

2.  The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs.

Authors:  H W Mitchell; M A Denborough
Journal:  Lung       Date:  1980       Impact factor: 2.584

3.  In vivo method for quantitation for anti-platelet potency of drugs.

Authors:  R J Gryglewski; R Korbut; A Ocetkiewicz; J Stachura
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-03       Impact factor: 3.000

4.  Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin.

Authors:  E Vinge
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Hyperthermic effects of arachidonic acid, prostaglandin E2 and F2alpha in rats.

Authors:  J A Spławiński; Z Górka; E Zacny; B Wojtaszek
Journal:  Pflugers Arch       Date:  1978-04-25       Impact factor: 3.657
  5 in total

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