Literature DB >> 934294

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.

P Needleman, S Moncada, S Bunting, J R Vane, M Hamberg, B Samuelsson.   

Abstract

The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting strips of rabbit aorta. This substance has the same characteristics as thromboxane A2, and can be distinguished from other products of arachidonic acid metabolism by differential bioassay.

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Year:  1976        PMID： 934294     DOI： 10.1038/261558a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  92 in total

1.  Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.

Authors:  M Bustos; T M Coffman; S Saadi; J L Platt
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

2.  Localization of thromboxane synthase in human tissues by monoclonal antibody Tü 300.

Authors:  R Nüsing; G Sauter; P Fehr; U Dürmüller; M Kasper; F Gudat; V Ullrich
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

3.  Nanoparticle-induced platelet aggregation and vascular thrombosis.

Authors:  Anna Radomski; Paul Jurasz; David Alonso-Escolano; Magdalena Drews; Maria Morandi; Tadeusz Malinski; Marek W Radomski
Journal:  Br J Pharmacol       Date:  2005-11       Impact factor: 8.739

Review 4.  Adventures in vascular biology: a tale of two mediators.

Authors:  S Moncada
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-05-29       Impact factor: 6.237

5.  Fe(II)-induced decomposition of epidioxides. A chemical model for prostaglandin E, prostacyclin and thromboxane biosynthesis.

Authors:  J A Turner; W Herz
Journal:  Experientia       Date:  1977-09-15

6.  Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

Authors:  E G Lapetina; K A Chandrabose; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

7.  Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5-hydroxy-tryptamine in the production of acute spasm.

Authors:  D J Boullin; G H Du Boulay; A T Rogers
Journal:  Br J Clin Pharmacol       Date:  1978-09       Impact factor: 4.335

Review 8.  Prostaglandins, thromboxanes, and polymorphonuclear leukocytes: mediation and modulation of inflammation.

Authors:  I M Goldstein; C L Malmsten; B Samuelsson; G Weissmann
Journal:  Inflammation       Date:  1977-12       Impact factor: 4.092

9.  Prostacyclin (PGI2) inhibits the formation of platelet thrombi in arterioles and venules of the hamster cheek pouch.

Authors:  E A Higgs; G A Higgs; S Moncada; J R Vane
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

10.  Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with prostacyclin and other prostanoids.

Authors:  A L Hyman; P J Kadowitz; W E Lands; C G Crawford; J Fried; J Barton
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205
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