Synthesis and pharmacological evaluation of some novel 5-(pyrazol-3-yl)thiadiazole and oxadiazole derivatives as potential hypoglycemic agents.

Four series of 5-(pyrazol-3-yl)thiadiazole and oxadiazole derivatives (Va-c, VIa-c, VIIIa-c, IXa-c) have been synthesized from 5-arylazo-3-carbethoxy-4-methoxy-1-phenylpyrazole (Ia-c) with a view to investigate their pharmacological activity. The structure of the synthesized products was inferred from elemental and spectral data. The hypoglycemic effect, antimicrobial activity and toxicity of these potential chemotherapeutic agents were evaluated. Nineteen of these products were effective, when administered at an oral dose of 100 mg/kg body weight in inducing a marked reduction in blood glucose level.