Literature DB >> 8594346

Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors, and an antibody Fab fragment.

A D Clark1, A Jacobo-Molina, P Clark, S H Hughes, E Arnold.   

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Year:  1995        PMID： 8594346     DOI： 10.1016/0076-6879(95)62017-6

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


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  14 in total

1.  A novel non-radioactive assay for HIV-RT (RdDp) based on pyrosequencing for high-throughput drug screening.

Authors:  Chang Zhang; Yang Wu; Yuna Sun; Chuan Hong; Kehui Xiang; Yu Guo; Mark Bartlam; Zhiyong Lou
Journal:  Protein Cell       Date:  2010-02-24       Impact factor: 14.870

2.  Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.

Authors:  S Loya; H Q Gao; O Avidan; P L Boyer; S H Hughes; A Hizi
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

3.  Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Authors:  Suhman Chung; Daniel M Himmel; Jian-Kang Jiang; Krzysztof Wojtak; Joseph D Bauman; Jason W Rausch; Jennifer A Wilson; John A Beutler; Craig J Thomas; Eddy Arnold; Stuart F J Le Grice
Journal:  J Med Chem       Date:  2011-06-02       Impact factor: 7.446

4.  Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation.

Authors:  Ryan L Slack; Tatiana V Ilina; Zhaoyong Xi; Nicholas S Giacobbi; Gota Kawai; Michael A Parniak; Stefan G Sarafianos; Nicolas Sluis Cremer; Rieko Ishima
Journal:  Structure       Date:  2019-08-27       Impact factor: 5.006

5.  Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.

Authors:  Zhaoyong Xi; Zhengqiang Wang; Stefan G Sarafianos; Nataliya S Myshakina; Rieko Ishima
Journal:  ACS Infect Dis       Date:  2019-10-02       Impact factor: 5.084

6.  Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

Authors:  S G Sarafianos; K Das; C Tantillo; A D Clark; J Ding; J M Whitcomb; P L Boyer; S H Hughes; E Arnold
Journal:  EMBO J       Date:  2001-03-15       Impact factor: 11.598

7.  HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

Authors:  Daniel M Himmel; Stefan G Sarafianos; Sanjeewa Dharmasena; Mohammed M Hossain; Kessler McCoy-Simandle; Tatiana Ilina; Arthur D Clark; Jennifer L Knight; John G Julias; Patrick K Clark; Karsten Krogh-Jespersen; Ronald M Levy; Stephen H Hughes; Michael A Parniak; Eddy Arnold
Journal:  ACS Chem Biol       Date:  2006-12-20       Impact factor: 5.100

8.  Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Authors:  Daniel M Himmel; Karen A Maegley; Tom A Pauly; Joseph D Bauman; Kalyan Das; Chhaya Dharia; Arthur D Clark; Kevin Ryan; Michael J Hickey; Robert A Love; Stephen H Hughes; Simon Bergqvist; Eddy Arnold
Journal:  Structure       Date:  2009-12-09       Impact factor: 5.006

9.  The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site.

Authors:  Naima G Sharaf; Zhaoyong Xi; Rieko Ishima; Angela M Gronenborn
Journal:  Proteins       Date:  2017-09-26

10.  High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Authors:  Kalyan Das; Joseph D Bauman; Arthur D Clark; Yulia V Frenkel; Paul J Lewi; Aaron J Shatkin; Stephen H Hughes; Eddy Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-29       Impact factor: 11.205
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