Literature DB >> 8593420

Binding site for basic drugs on alpha 1-acid glycoprotein as revealed by chemometric analysis of biochromatographic data.

R Kaliszan1, A Nasal, M Turowski.   

Abstract

Interactions between alpha 1-acid glycoprotein (AGP) and 52 basic drugs were quantified by means of high-performance liquid chromatography (HPLC). The HPLC retention parameters were related quantitatively to the hydrophobicity and molecular modelling parameters, giving rise to the prediction of relative drug-AGP binding from the chemical structure of a drug. A structural model of one binding site on AGP, common for various classes of drugs, was defined which accounted for the observed and reported differences in binding to AGP. A combination of biochromatography and chemometrics has been presented as a promising new approach in biochemical/pharmacological studies.

Mesh：

Substances：

Year:  1995        PMID： 8593420     DOI： 10.1002/bmc.1130090504

Source DB:  PubMed          Journal:  Biomed Chromatogr        ISSN： 0269-3879            Impact factor:   1.902


  9 in total

Review 1.  Characterization of drug interactions with serum proteins by using high-performance affinity chromatography.

Authors:  David S Hage; Jeanethe Anguizola; Omar Barnaby; Abby Jackson; Michelle J Yoo; Efthimia Papastavros; Erika Pfaunmiller; Matt Sobansky; Zenghan Tong
Journal:  Curr Drug Metab       Date:  2011-05       Impact factor: 3.731

Review 2.  Studies of metabolite-protein interactions: a review.

Authors:  Ryan Matsuda; Cong Bi; Jeanethe Anguizola; Matthew Sobansky; Elliott Rodriguez; John Vargas Badilla; Xiwei Zheng; Benjamin Hage; David S Hage
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2013-11-25       Impact factor: 3.205

Review 3.  Analysis of biomolecular interactions using affinity microcolumns: a review.

Authors:  Xiwei Zheng; Zhao Li; Sandya Beeram; Maria Podariu; Ryan Matsuda; Erika L Pfaunmiller; Christopher J White; NaTasha Carter; David S Hage
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2014-01-27       Impact factor: 3.205

Review 4.  Characterization of drug-protein interactions in blood using high-performance affinity chromatography.

Authors:  David S Hage; Abby Jackson; Matthew R Sobansky; John E Schiel; Michelle J Yoo; K S Joseph
Journal:  J Sep Sci       Date:  2009-03       Impact factor: 3.645

5.  On-column entrapment of alpha1-acid glycoprotein for studies of drug-protein binding by high-performance affinity chromatography.

Authors:  Jeanethe Anguizola; Cong Bi; Michelle Koke; Abby Jackson; David S Hage
Journal:  Anal Bioanal Chem       Date:  2016-06-11       Impact factor: 4.142

6.  CHROMATOGRAPHIC ANALYSIS OF DRUG INTERACTIONS IN THE SERUM PROTEOME.

Authors:  David S Hage; Jeanethe A Anguizola; Abby J Jackson; Ryan Matsuda; Efthimia Papastavros; Erika Pfaunmiller; Zenghan Tong; John Vargas-Badilla; Michelle J Yoo; Xiwei Zheng
Journal:  Anal Methods       Date:  2011-07-01       Impact factor: 2.896

7.  Development and validation of quantitative structure-activity relationship models for compounds acting on serotoninergic receptors.

Authors:  Grażyna Zydek; Elżbieta Brzezińska
Journal:  ScientificWorldJournal       Date:  2012-04-24

8.  Rapid detection and identification of overdose drugs in saliva by surface-enhanced Raman scattering using fused gold colloids.

Authors:  Stuart Farquharson; Chetan Shende; Atanu Sengupta; Hermes Huang; Frank Inscore
Journal:  Pharmaceutics       Date:  2011-07-13       Impact factor: 6.321

9.  Biomimetic properties and estimated in vivo distribution of chloroquine and hydroxy-chloroquine enantiomers.

Authors:  Klara L Valko; Tong Zhang
Journal:  ADMET DMPK       Date:  2020-01-25
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.