Literature DB >> 858775

Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

J Takahara, S Yunoki, W Yakushiji, J Yamauchi, Y Yamane.   

Abstract

A dose of 2.5 g of gamma-hydroxybutyric acid (GHB) was administered intravenously to 6 healthy male volunteers. A significant increase in plasma GH was observed at 30, 45, 60 and 90 min after injection. The plasma prolactin level increased significantly at 45 and 60 min after GHB injection. These responses were not found after the saline vehicle injection in the same subjects. It is conceivable that GHB could modify the release of serotonin from the nerve terminals and then stimulate the release of GH and prolactin.

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Year:  1977        PMID: 858775     DOI: 10.1210/jcem-44-5-1014

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN: 0021-972X            Impact factor:   5.958


  30 in total

Review 1.  An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway.

Authors:  E E Kaufman; T Nelson
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

2.  Acute poisoning from gamma-hydroxybutyrate in California.

Authors:  M Y Chin; R A Kreutzer; J E Dyer
Journal:  West J Med       Date:  1992-04

Review 3.  Alternative drugs of abuse.

Authors:  M E Sutter; J Chenoweth; T E Albertson
Journal:  Clin Rev Allergy Immunol       Date:  2014-02       Impact factor: 8.667

4.  Evidence for a GABAergic control of the exercise-induced rise in GH in man.

Authors:  L Steardo; M Iovino; P Monteleone; M Agrusta; F Orio
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Alterations in gene expression after gamma-hydroxybutyric acid intake-A pilot study.

Authors:  Lena-Maria Mehling; Annika Spottke; Anna Heidbreder; Peter Young; Burkhard Madea; Cornelius Hess; Cornelius Courts
Journal:  Int J Legal Med       Date:  2017-05-22       Impact factor: 2.686

6.  Effect of long-term treatment with sodium valproate on gonadotrophin and prolactin secretion in paediatric patients.

Authors:  A Masala; T Meloni; S Alagna; P P Rovasio; S Rassu; G Mele; V Franca
Journal:  Br J Clin Pharmacol       Date:  1981-12       Impact factor: 4.335

7.  A neuroendocrine approach to benzodiazepine tolerance and dependence.

Authors:  H Petursson; E Shur; S Checkley; A Slade; M H Lader
Journal:  Br J Clin Pharmacol       Date:  1981-05       Impact factor: 4.335

8.  Intravenous alprazolam challenge in normal subjects. Biochemical, cardiovascular, and behavioral effects.

Authors:  E D Risby; J K Hsiao; R N Golden; W Z Potter
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

9.  Dose-dependent effects of intravenous alprazolam on neuroendocrine, biochemical, cardiovascular, and behavioral parameters in humans.

Authors:  O T Osman; J K Hsiao; W Z Potter
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Dose-related effects of gamma-amino beta-hydroxy butyric acid (GABOB) infusion on growth hormone secretion in normal women.

Authors:  G B Melis; A M Paoletti; V Mais; N M Mastrapasqua; F Strigini; F Fruzzetti; G Guarnieri; M Gambacciani; P Fioretti
Journal:  J Endocrinol Invest       Date:  1982 Mar-Apr       Impact factor: 4.256

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