Literature DB >> 3930260

Evidence for a GABAergic control of the exercise-induced rise in GH in man.

L Steardo, M Iovino, P Monteleone, M Agrusta, F Orio.   

Abstract

The effect of the GABAergic drug sodium valproate (SV) on the exercise-induced release of growth hormone (GH) was investigated in 10 healthy males. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. SV 600 mg blunted the increase in GH induced by the exercise, suggesting GABAergic regulation of GH secretion in man, at least under certain physiological conditions.

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Year:  1985        PMID： 3930260     DOI： 10.1007/bf00544075

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  19 in total

1.  In vitro studies into the effect of inhibition of rat brain succinic semialdehyde dehydrogenase on GABA synthesis and degradation.

Authors:  M Maitre; L Ossola; P Mandel
Journal:  FEBS Lett       Date:  1976-12-15       Impact factor: 4.124

2.  Effects of a gamma aminobutyric acid (GABA) derivative, baclofen, on growth hormone and prolactin secretion in man.

Authors:  F Cavagnini; C Invitti; A Di Landro; L Tenconi; C Maraschini; G Girotti
Journal:  J Clin Endocrinol Metab       Date:  1977-09       Impact factor: 5.958

3.  Localization of GABAergic, cholinergic and aminergic structures in the mesolimbic system.

Authors:  F Fonnum; I Walaas; E Iversen
Journal:  J Neurochem       Date:  1977-08       Impact factor: 5.372

Review 4.  Biochemical physiology of central synapses.

Authors:  R J Baldessarini; M Karobath
Journal:  Annu Rev Physiol       Date:  1973       Impact factor: 19.318

5.  Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism.

Authors:  Y Godin; L Heiner; J Mark; P Mandel
Journal:  J Neurochem       Date:  1969-06       Impact factor: 5.372

Review 6.  Central actions of valproic acid in man and in experimental models of epilepsy.

Authors:  E J Hammond; B J Wilder; J Bruni
Journal:  Life Sci       Date:  1981-12-21       Impact factor: 5.037

7.  Lack of modulation of pituitary hormone stress response by neural pathways involving opiate receptors.

Authors:  I J Spiler; M E Molitch
Journal:  J Clin Endocrinol Metab       Date:  1980-03       Impact factor: 5.958

8.  The effect of methysergide, pimozide, and sodium valproate on the diazepam-stimulated growth hormone secretion in man.

Authors:  M Koulu; R Lammintausta; L Kangas; S Dahlström
Journal:  J Clin Endocrinol Metab       Date:  1979-01       Impact factor: 5.958

9.  Effects of some gamma-aminobutyric acid (GABA)-ergic drugs on the dopaminergic control of human growth hormone secretion.

Authors:  M Koulu; R Lammintausta; S Dahlström
Journal:  J Clin Endocrinol Metab       Date:  1980-07       Impact factor: 5.958

10.  Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

Authors:  J Takahara; S Yunoki; W Yakushiji; J Yamauchi; Y Yamane
Journal:  J Clin Endocrinol Metab       Date:  1977-05       Impact factor: 5.958
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  1 in total

1.  Impaired growth hormone response to sodium valproate in normal aging.

Authors:  P Monteleone; M Iovino; F Orio; L Steardo
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  1 in total

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