Literature DB >> 8587143

Repetitive DNA sequences located in the central region of the human mdr1 (multidrug resistance) gene may account for a gene fusion event during its evolution.

M Pauly1, I Kayser, M Schmitz, F Ries, F Hentges, M Dicato.   

Abstract

The mdr1 gene, first member of the human multidrug-resistance gene family, is a major gene involved in cellular resistance to several drugs used in anticancer chemotherapy. Its product, the drug-excreting P-glycoprotein, shows a bipartite structure formed by two similar adjacent halves. According to one hypothesis, the fusion of two related ancestral genes during evolution could have resulted in this structure. The DNA sequence analysis of the introns located in the region connecting the two halves of the human mdr1 gene revealed a highly conserved poly(CA).poly (TG) sequence in intron 15 and repeated sequences of the Alu family in introns 14 and 17. These repeated sequences most likely represent "molecular fossils" of ancient DNA elements which were involved in such a recombination event.

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Year:  1995        PMID： 8587143     DOI： 10.1007/bf00173178

Source DB:  PubMed          Journal:  J Mol Evol        ISSN： 0022-2844            Impact factor:   2.395


  18 in total

1.  Identification of homologous pairing and strand-exchange activity from a human tumor cell line based on Z-DNA affinity chromatography.

Authors:  R A Fishel; K Detmer; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

2.  Z-DNA in transcriptionally active chromosomes.

Authors:  F Lancillotti; M C Lopez; P Arias; C Alonso
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

3.  Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

Authors:  D F Callen; E Baker; R N Simmers; R Seshadri; I B Roninson
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

4.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Authors:  J L Weber; P E May
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

5.  The Z-DNA motif d(TG)30 promotes reception of information during gene conversion events while stimulating homologous recombination in human cells in culture.

Authors:  W P Wahls; L J Wallace; P D Moore
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

Review 6.  Biochemistry of multidrug resistance mediated by the multidrug transporter.

Authors:  M M Gottesman; I Pastan
Journal:  Annu Rev Biochem       Date:  1993       Impact factor: 23.643

7.  The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis.

Authors:  D Treco; N Arnheim
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

8.  Association of poly(CA).poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2.

Authors:  C Gaillard; F Strauss
Journal:  Science       Date:  1994-04-15       Impact factor: 47.728

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

Authors:  C J Chen; D Clark; K Ueda; I Pastan; M M Gottesman; I B Roninson
Journal:  J Biol Chem       Date:  1990-01-05       Impact factor: 5.157
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  1 in total

1.  Scapharca inaequivalvis tetrameric hemoglobin A and B chains: cDNA sequencing and genomic organization.

Authors:  M C Piro; A Gambacurta; F Ascoli
Journal:  J Mol Evol       Date:  1996-12       Impact factor: 2.395
  1 in total

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