Literature DB >> 8586977

Elemental imbalances in the olfactory pathway in Alzheimer's disease.

D L Samudralwar1, C C Diprete, B F Ni, W D Ehmann, W R Markesbery.   

Abstract

Concentrations of 11 trace elements were determined in 56 control and 98 Alzheimer's disease (AD) olfactory bulb, olfactory tract, olfactory trigone, piriform cortex and amygdala specimens by instrumental neutron activation analysis. Iron and zinc were significantly elevated and bromine was significantly depleted in olfactory regions of AD patients, compared with normal age-matched control subjects. Elevated iron could possibly play a role in neuronal degeneration in AD by enhancing reactive free radical formation.

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Year:  1995        PMID： 8586977     DOI： 10.1016/0022-510x(95)00018-w

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  31 in total

1.  In vivo reduction of amyloid-beta by a mutant copper transporter.

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2.  The effect of formalin fixation on the levels of brain transition metals in archived samples.

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Review 3.  Oxidative imbalance in Alzheimer's disease.

Authors:  Xiongwei Zhu; Hyoung-Gon Lee; Gemma Casadesus; Jesus Avila; Kelly Drew; George Perry; Mark A Smith
Journal:  Mol Neurobiol       Date:  2005       Impact factor: 5.590

4.  Neuroprotection by 7-nitroindazole against iron-induced hippocampal neurotoxicity.

Authors:  M Omer Bostanci; Faruk Bağirici
Journal:  Cell Mol Neurobiol       Date:  2007-10-27       Impact factor: 5.046

5.  Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century.

Authors:  Wing-Hin Lee; Ching-Yee Loo; Mary Bebawy; Frederick Luk; Rebecca S Mason; Ramin Rohanizadeh
Journal:  Curr Neuropharmacol       Date:  2013-07       Impact factor: 7.363

Review 6.  In situ imaging of metals in cells and tissues.

Authors:  Reagan McRae; Pritha Bagchi; S Sumalekshmy; Christoph J Fahrni
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

7.  Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion.

Authors:  Matthew Schrag; Claudius Mueller; Udochukwu Oyoyo; Mark A Smith; Wolff M Kirsch
Journal:  Prog Neurobiol       Date:  2011-05-11       Impact factor: 11.685

8.  Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease.

Authors:  M A Lovell; J L Smith; S Xiong; W R Markesbery
Journal:  Neurotox Res       Date:  2005       Impact factor: 3.911

9.  Serum zinc in the progression of Alzheimer's disease.

Authors:  Jiang Dong; J David Robertson; William R Markesbery; Mark A Lovell
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472

Review 10.  A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.

Authors:  Mark A Lovell
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472
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