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Literature DB >> 8580708

The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system.

Abstract

The GAL4 system is a method for directed gene expression that allows genes to be expressed ectopically in numerous cell- or tissue-specific patterns. The technique is being exploited to study the Drosophila melanogaster nervous system at all stages of development, from the embryo to the adult. The GAL4 system is being used to target the expression of novel marker genes in living animals to label cells, or subcellular structures. Directed expression of toxin genes can be used as a method for targeted cell ablation to study the role of cell-cell interactions in development. Ectopic expression helps to elucidate the function of different genes in cell fate determination and differentiation, and is helping to define the regions of the brain involved in sexual behaviour.

Entities: Disease Gene

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Year: 1995 PMID： 8580708 DOI： 10.1016/0959-4388(95)80061-1

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

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Cited

34 in total

Review 1. Ten years of enhancer detection: lessons from the fly.

Authors: H J Bellen
Journal: Plant Cell Date: 1999-12 Impact factor: 11.277

2. Visual input regulates circuit configuration in courtship conditioning of Drosophila melanogaster.

Authors: M A Joiner; L C Griffith
Journal: Learn Mem Date: 2000-01 Impact factor: 2.460

3. A conditional tissue-specific transgene expression system using inducible GAL4.

Authors: T Osterwalder; K S Yoon; B H White; H Keshishian
Journal: Proc Natl Acad Sci U S A Date: 2001-10-23 Impact factor: 11.205

4. Mapping of the anatomical circuit of CaM kinase-dependent courtship conditioning in Drosophila.

Authors: M A Joiner; L C Griffith
Journal: Learn Mem Date: 1999 Mar-Apr Impact factor: 2.460

5. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span.

Authors: Mohan Sarkar; Konstantin G Iliadi; Peter A Leventis; Harry Schachter; Gabrielle L Boulianne
Journal: Proc Natl Acad Sci U S A Date: 2010-05-10 Impact factor: 11.205

The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system.

Review 1. Ten years of enhancer detection: lessons from the fly.

2. Visual input regulates circuit configuration in courtship conditioning of Drosophila melanogaster.

3. A conditional tissue-specific transgene expression system using inducible GAL4.

4. Mapping of the anatomical circuit of CaM kinase-dependent courtship conditioning in Drosophila.

5. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span.

6. NeuronMetrics: software for semi-automated processing of cultured neuron images.

7. Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish.

8. A novel paradigm for nonassociative long-term memory in Drosophila: predator-induced changes in oviposition behavior.

9. New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish.

10. Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR.