| Literature DB >> 8576922 |
S G Rahim1, N Trivedi, M V Bogunovic-Batchelor, G W Hardy, G Mills, J W Selway, W Snowden, E Littler, P L Coe, I Basnak, R F Whale, R T Walker.
Abstract
A series of 5-substituted 2'-deoxy-4'-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as 2'-deoxy-5-propyl-4'-thiouridine (3ii), 2'-deoxy-5-isopropyl-4'-thiouridine (3iii), 5-cyclopropyl-2'-deoxy-4'-thiouridine (3iv), 2'-deoxy-4'-thio-5-vinyluridine (3viii), and 5-(2-chloroethyl)-2'-deoxy-4'-thiouridine (3xx) were found to be highly active against herpes simplex virus type-1 (HSV-1) and varicella zoster virus (VZV) in vitro with no significant cytotoxicity. The compound with the broadest spectrum of activity was 2'-deoxy-5-ethyl-4'-thiouridine (3i) which showed significant activity against HSV-1, HSV-2, and VZV.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8576922 DOI： 10.1021/jm950029r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446