K Yamane1, T Sato, T Tanaka, Y Tsuji. 1. Department of Quality Control, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
Abstract
PURPOSE: The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation. METHODS: DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation. RESULTS: The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers. CONCLUSIONS: It is found that DEM is a useful method of predicting tablet motion in a coating drum.
PURPOSE: The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation. METHODS:DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation. RESULTS: The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers. CONCLUSIONS: It is found that DEM is a useful method of predicting tablet motion in a coating drum.
Authors: Sarah Just; Gregor Toschkoff; Adrian Funke; Dejan Djuric; Georg Scharrer; Johannes Khinast; Klaus Knop; Peter Kleinebudde Journal: AAPS PharmSciTech Date: 2013-01-25 Impact factor: 3.246