Literature DB >> 23325382

Angular circulation speed of tablets in a vibratory tablet coating pan.

Rahul Kumar1, Carl Wassgren.   

Abstract

In this work, a single tablet model and a discrete element method (DEM) computer simulation are developed to obtain the angular circulation speed of tablets in a vibratory tablet coating pan for range of vibration frequencies and amplitudes. The models identify three important dimensionless parameters that influence the speed of the tablets: the dimensionless amplitude ratio (a/R), the Froude number (aω2/g), and the tablet-wall friction coefficient, where a is the peak vibration amplitude at the drum center, ω is the vibration angular frequency, R is the drum radius, and g is the acceleration due to gravity. The models predict that the angular circulation speed of tablets increases with an increase in each of these parameters. The rate of increase in the angular circulation speed is observed to decrease for larger values of a/R. The angular circulation speed reaches an asymptote beyond a tablet-wall friction coefficient value of about 0.4. Furthermore, it is found that the Froude number should be greater than one for the tablets to start circulating. The angular circulation speed increases as Froude number increases but then does not change significantly at larger values of the Froude number. Period doubling, where the motion of the bed is repeated every two cycles, occurs at a Froude number larger than five. The single tablet model, although much simpler than the DEM model, is able to predict the maximum circulation speed (the limiting case for a large value of tablet-wall friction coefficient) as well as the transition to period doubling.

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Year:  2013        PMID: 23325382      PMCID: PMC3581638          DOI: 10.1208/s12249-012-9917-x

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN: 1530-9932            Impact factor:   3.246


  6 in total

1.  The coefficient of restitution of some pharmaceutical tablets/compacts.

Authors:  Rahul Bharadwaj; Carson Smith; Bruno C Hancock
Journal:  Int J Pharm       Date:  2010-09-29       Impact factor: 5.875

2.  Stress results from two-dimensional granular shear flow simulations using various collision models.

Authors:  William R Ketterhagen; Jennifer S Curtis; Carl R Wassgren
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2005-06-30

3.  Evaluation of recent advances in continuous film coating processes.

Authors:  Charles Cunningham; Jason Hansell; Frank Nuneviller; Ali R Rajabi-Siahboomi
Journal:  Drug Dev Ind Pharm       Date:  2010-02       Impact factor: 3.225

4.  Effect of particle size on energy dissipation in viscoelastic granular collisions.

Authors:  Dmytro Antypov; James A Elliott; Bruno C Hancock
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2011-08-08

5.  A photometric analysis of tablet movement in a side-vented perforated drum (Accela-Cota).

Authors:  T M Leaver; H D Shannon; R C Rowe
Journal:  J Pharm Pharmacol       Date:  1985-01       Impact factor: 3.765

6.  Computer simulation of tablet motion in coating drum.

Authors:  K Yamane; T Sato; T Tanaka; Y Tsuji
Journal:  Pharm Res       Date:  1995-09       Impact factor: 4.200

  6 in total
  1 in total

1.  Validating a Numerical Simulation of the ConsiGma(R) Coater.

Authors:  Peter Boehling; Dalibor Jacevic; Frederik Detobel; James Holman; Laura Wareham; Matthew Metzger; Johannes G Khinast
Journal:  AAPS PharmSciTech       Date:  2020-11-26       Impact factor: 3.246

  1 in total

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