Literature DB >> 8567160

The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats.

O Risto1, O Wahlström, A Abdiu.   

Abstract

The effect of a low dose of diclofenac sodium, administered locally, on heterotopic bone formation in rats was investigated. Heterotopic bone was induced by implantation of demineralised bone matrix into the gluteal muscles. Diclofenac was released continuously for 2 weeks from micro-osmotic pumps for each demineralised bone implant in the rats. Each had a control implant in the opposite gluteal muscle to which saline was released in the same way. The yield of new woven bone was determined after 4 weeks by measuring the ash-weights of the implants. Those of the diclofenac samples were significantly decreased compared to the controls. These results suggest that a low dose of diclofenac given locally decreases heterotopic bone formation in rats.

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Year:  1995        PMID： 8567160     DOI： 10.1007/bf00178357

Source DB:  PubMed          Journal:  Int Orthop        ISSN： 0341-2695            Impact factor:   3.075


  13 in total

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Authors:  P Aspenberg; L S Lohmander
Journal:  Acta Orthop Scand       Date:  1989-08

2.  Influence of indomethacin on induced heterotopic bone formation in rats. Importance of length of treatment and of age.

Authors:  O S Nilsson; H C Bauer; O Brosjö; H Törnkvist
Journal:  Clin Orthop Relat Res       Date:  1986-06       Impact factor: 4.176

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Authors:  E Elmstedt; T S Lindholm; O S Nilsson; H Törnkvist
Journal:  Acta Orthop Scand       Date:  1985-02

5.  The osteoinductive capacity of differently HCl-decalcified bone alloimplants.

Authors:  C Delloye; A Hebrant; E Munting; L Piret; L Coutelier
Journal:  Acta Orthop Scand       Date:  1985-08

6.  The use of indomethacin to prevent the formation of heterotopic bone after total hip replacement. A randomized, double-blind clinical trial.

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Journal:  J Bone Joint Surg Am       Date:  1988-07       Impact factor: 5.284

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Authors:  H Törnkvist; O S Nilsson; F C Bauer; T S Lindholm
Journal:  Scand J Rheumatol       Date:  1983       Impact factor: 3.641

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Authors:  J Bo; E Sudmann; P F Marton
Journal:  Acta Orthop Scand       Date:  1976-12

9.  Indomethacin for prevention of heterotopic ossification. A randomized controlled study in 41 hip arthroplasties.

Authors:  P Kjaersgaard-Andersen; A Nafei; G Teichert; O Kristensen; S A Schmidt; J Keller; U Lucht
Journal:  Acta Orthop Scand       Date:  1993-12

10.  A comparison of indomethacin and diclofenac in the inhibition of experimental heterotopic new bone formation.

Authors:  O S Nilsson; H C Bauer; O Brosjö; H Törnkvist
Journal:  Int Orthop       Date:  1987       Impact factor: 3.075
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  3 in total

Review 1.  Prevention of heterotopic ossification after total hip replacement with NSAIDs.

Authors:  Roel Fijn; Rinco Th Koorevaar; Jacobus R Brouwers
Journal:  Pharm World Sci       Date:  2003-08

2.  [Diclofenac inhibits proliferation and matrix formation of osteoblast cells].

Authors:  D Kaspar; C M Hedrich; C Schmidt; A Liedert; L E Claes; A A Ignatius
Journal:  Unfallchirurg       Date:  2005-01       Impact factor: 1.000

3.  The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study.

Authors:  Mujgan Gungor Hatipoglu; Sermet Inal; Sahin Kabay; Muhammet Kasim Cayci; Ayşenur Deger; Halil Isa Kuru; Sayit Altikat; Gizem Akkas
Journal:  Acta Stomatol Croat       Date:  2015-12
  3 in total

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