Literature DB >> 8564950

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

J Meerabux1, M L Yaspo, A J Roebroek, W J Van de Ven, T A Lister, B D Young.   

Abstract

A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.

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Year:  1996        PMID： 8564950

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  23 in total

1.  Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage.

Authors:  E D Anderson; J K VanSlyke; C D Thulin; F Jean; G Thomas
Journal:  EMBO J       Date:  1997-04-01       Impact factor: 11.598

2.  The proprotein convertase PC7: unique zymogen activation and trafficking pathways.

Authors:  Estelle Rousselet; Suzanne Benjannet; Josée Hamelin; Maryssa Canuel; Nabil G Seidah
Journal:  J Biol Chem       Date:  2010-11-12       Impact factor: 5.157

3.  A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.

Authors:  Akihiko Tsuji; Yayoi Kikuchi; Yukimi Sato; Shizuyo Koide; Keizo Yuasa; Masami Nagahama; Yoshiko Matsuda
Journal:  Biochem J       Date:  2006-05-15       Impact factor: 3.857

4.  A model for the structure of the P domains in the subtilisin-like prohormone convertases.

Authors:  G M Lipkind; A Zhou; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

5.  PACE4: a subtilisin-like endoprotease with unique properties.

Authors:  R E Mains; C A Berard; J B Denault; A Zhou; R C Johnson; R Leduc
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

6.  Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids.

Authors:  W Dong; B Seidel; M Marcinkiewicz; M Chrétien; N G Seidah; R Day
Journal:  J Neurosci       Date:  1997-01-15       Impact factor: 6.167

7.  Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.

Authors:  K Scougall; N A Taylor; J L Jermany; K Docherty; K I Shennan
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

8.  Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments.

Authors:  S Wouters; M Leruth; E Decroly; M Vandenbranden; J W Creemers; J W van de Loo; J M Ruysschaert; P J Courtoy
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857

9.  Gene organization and alternative splicing of human prohormone convertase PC8.

Authors:  K A Goodge; R J Thomas; T J Martin; M T Gillespie
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857

10.  Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1).

Authors:  Kazuya Ueda; Gregory M Lipkind; An Zhou; Xiaorong Zhu; Andrey Kuznetsov; Louis Philipson; Paul Gardner; Chunling Zhang; Donald F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-29       Impact factor: 11.205
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