Literature DB >> 9820806

Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments.

S Wouters1, M Leruth, E Decroly, M Vandenbranden, J W Creemers, J W van de Loo, J M Ruysschaert, P J Courtoy.   

Abstract

The intracellular compartmentalization in rat liver of the membrane-associated convertases furin and proprotein convertase 7 (PC7)/lymphoma PC (LPC) was investigated by analytical subcellular fractionation. In control animals, both enzymes were found to localize in fractions depleted of endoplasmic reticulum, cis-Golgi and lysosomal markers, but to co-distribute with the Golgi marker galactosyltransferase and the trans-Golgi network (TGN) marker TGN38. After overloading Golgi-derived vesicles with very-low-density lipoproteins (VLDL) by feeding rats with ethanol, the distribution of PC7/LPC was shifted markedly towards lower densities, in contrast with those of furin and the TGN marker. This provides support for the TGN localization of endogenously expressed furin and indicates that, at steady state, a considerable proportion of PC7/LPC may be associated with vesicles derived from the TGN.

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Year:  1998        PMID： 9820806      PMCID： PMC1219873          DOI： 10.1042/bj3360311

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  51 in total

1.  Studies on glucosaminidase. 4. The fluorimetric assay of N-acetyl-beta-glucosaminidase.

Authors:  D H LEABACK; P G WALKER
Journal:  Biochem J       Date:  1961-01       Impact factor: 3.857

2.  Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors:  C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal:  Biochem J       Date:  1955-08       Impact factor: 3.857

3.  Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.

Authors:  J W van de Loo; J W Creemers; N A Bright; B D Young; A J Roebroek; W J Van de Ven
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4.  Cellular distributions of the prohormone processing enzymes PC1 and PC2.

Authors:  I Lindberg; S C Ahn; M B Breslin
Journal:  Mol Cell Neurosci       Date:  1994-12       Impact factor: 4.314

5.  Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum.

Authors:  J W Creemers; M Vey; W Schäfer; T A Ayoubi; A J Roebroek; H D Klenk; W Garten; W J Van de Ven
Journal:  J Biol Chem       Date:  1995-02-10       Impact factor: 5.157

Review 6.  The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

Authors:  N G Seidah; M Chrétien; R Day
Journal:  Biochimie       Date:  1994       Impact factor: 4.079

7.  Characterization of a secreted form of human furin endoprotease.

Authors:  G Vidricaire; J B Denault; R Leduc
Journal:  Biochem Biophys Res Commun       Date:  1993-09-15       Impact factor: 3.575

8.  An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.

Authors:  P Voorhees; E Deignan; E van Donselaar; J Humphrey; M S Marks; P J Peters; J S Bonifacino
Journal:  EMBO J       Date:  1995-10-16       Impact factor: 11.598

9.  The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

Authors:  H Bosshart; J Humphrey; E Deignan; J Davidson; J Drazba; L Yuan; V Oorschot; P J Peters; J S Bonifacino
Journal:  J Cell Biol       Date:  1994-09       Impact factor: 10.539

10.  Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

Authors:  W Schäfer; A Stroh; S Berghöfer; J Seiler; M Vey; M L Kruse; H F Kern; H D Klenk; W Garten
Journal:  EMBO J       Date:  1995-06-01       Impact factor: 11.598
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  13 in total

Review 1.  The zona pellucida in folliculogenesis, fertilization and early development.

Authors:  Ming Zhao; Jurrien Dean
Journal:  Rev Endocr Metab Disord       Date:  2002-01       Impact factor: 6.514

2.  Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.

Authors:  J C Lissitzky; J Luis; J S Munzer; S Benjannet; F Parat; M Chrétien; J Marvaldi; N G Seidah
Journal:  Biochem J       Date:  2000-02-15       Impact factor: 3.857

3.  Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.

Authors:  J W van de Loo; M Teuchert; I Pauli; E Plets; W J Van de Ven; J W Creemers
Journal:  Biochem J       Date:  2000-12-15       Impact factor: 3.857

4.  Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.

Authors:  Jeroen Declercq; Sandra Meulemans; Evelyn Plets; John W M Creemers
Journal:  J Biol Chem       Date:  2012-01-30       Impact factor: 5.157

5.  Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.

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Journal:  J Virol       Date:  2010-02-24       Impact factor: 5.103

Review 6.  Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.

Authors:  Philipp Stawowy; Eckart Fleck
Journal:  J Mol Med (Berl)       Date:  2005-10-22       Impact factor: 4.599

7.  Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.

Authors:  C M Dubois; F Blanchette; M H Laprise; R Leduc; F Grondin; N G Seidah
Journal:  Am J Pathol       Date:  2001-01       Impact factor: 4.307

8.  Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice.

Authors:  Ming Zhao; Lyn Gold; Ann M Ginsberg; Li-Fang Liang; Jurrien Dean
Journal:  Mol Cell Biol       Date:  2002-05       Impact factor: 4.272

9.  Endosomal proteolysis of internalised [ArgA0]-human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo.

Authors:  M Kouach; B Desbuquois; F Authier
Journal:  Diabetologia       Date:  2009-10-16       Impact factor: 10.122

10.  An arginine stretch limits ADAM10 exit from the endoplasmic reticulum.

Authors:  Elena Marcello; Fabrizio Gardoni; Monica Di Luca; Isabel Pérez-Otaño
Journal:  J Biol Chem       Date:  2010-01-25       Impact factor: 5.157
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