Gustatory function in the parabrachial nuclei: implications from lesion studies in rats.

In rodents, third order gustatory neurons reside in the parabrachial nuclei of the dorsal pons. Lesions in this area of the brain have a variety of consequences on taste-related behaviors. Some behaviors are severely impaired, such as the expression of either conditioned taste aversion or depletion-induced sodium appetite. Other taste-based behaviors are less affected or not influenced at all. Although the lesion-behavior approach possesses serious methodological limitations, the constellation of findings from studies employing this experimental strategy in the PBN has promising implications. Foremost among these is the suggestion that the neural circuitry subserving performance in some of these taste-guided behavioral paradigms is dissociable. This paper critically reviews this body of behavioral research and discusses the conceptual ramifications of the results.