Literature DB >> 856217

Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor.

C W Castor, J C Ritchie, M E Scott, S L Whitney.   

Abstract

This report describes a small basic protein found in human platelets which stimulates hyaluronic acid formation, glucose uptake, and lactate formation in several types of human connective tissue cells. In addition, it stimulates in incorporation of [3H] methyl thymidine into DNA in human synovial cell cultures. This platelet factor (connective tissue activating peptide-II, CTAP-III) clearly differs form CTAP-I, found in human lymphocytes, and may play a role as a mediator of the inflammatory process.

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Year:  1977        PMID： 856217     DOI： 10.1002/art.1780200316

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  16 in total

1.  Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts.

Authors:  P Heldin; T C Laurent; C H Heldin
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

2.  The platelet as an inflammatory cell.

Authors:  R L Nachman; M Polley
Journal:  Trans Am Clin Climatol Assoc       Date:  1979

3.  Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

Authors:  C H Heldin; B Westermark; A Wasteson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

4.  Some in-vitro comparisons of synovial cells dispersed by trypsin from rheumatoid and nonrheumatoid synovium.

Authors:  B J Clarris; J R Fraser; J F Stanley
Journal:  Ann Rheum Dis       Date:  1981-06       Impact factor: 19.103

5.  Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

Authors:  C W Castor; J W Miller; D A Walz
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

6.  Hyaluronic acid and proteoglycan synthesis by lung fibroblasts in basal and activated states.

Authors:  C W Castor; T D Fremuth; A M Furlong; G W Jourdian
Journal:  In Vitro       Date:  1983-06

7.  Effect of soluble products from lectin-stimulated lymphocytes on the growth, adhesiveness, and glycosaminoglycan synthesis of cultured synovial fibroblastic cells.

Authors:  T P Anastassiades; A Wood
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

8.  Connective tissue activation in guinea pig lung fibroblast cultures: regulatory effects of glucocorticoids.

Authors:  J C Seidman; C W Castor
Journal:  In Vitro       Date:  1981-02

9.  Connective tissue activation. XXI. Regulation of glycosaminoglycan metabolism by lymphocyte (CTAP-I) and platelet (CTAP-III) growth factors.

Authors:  C W Castor; M C Bignall; P A Hossler; D J Roberts
Journal:  In Vitro       Date:  1981-09

10.  Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

Authors:  J H Korn; P V Halushka; E C LeRoy
Journal:  J Clin Invest       Date:  1980-02       Impact factor: 14.808
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