Literature DB >> 6873971

Hyaluronic acid and proteoglycan synthesis by lung fibroblasts in basal and activated states.

C W Castor, T D Fremuth, A M Furlong, G W Jourdian.   

Abstract

Most glycosaminoglycans (GAGs) formed by lung fibroblasts under both basal and stimulated conditions were secreted into the culture medium. High molecular weight (greater than 10(6) daltons) hyaluronic acid (HA) was the major GAG species formed. Most of the SO4-GAG synthesized by lung fibroblasts was of proteoglycan (PG) monomer size. Agents stimulating complex carbohydrate formation also exhibited some selectivity with respect to whether HA or PG was formed in incremental amounts. Hyaluronate synthesis was especially stimulated by endotoxins, SO4-GAG by beta-xylosides, and PG by CTAP-III.

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Year:  1983        PMID： 6873971     DOI： 10.1007/bf02619593

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  20 in total

1.  Fractionation of hyaluronic acid. The polydispersity of hyaluronic acid from the bovine vitreous body.

Authors:  T C LAURENT; M RYAN; A PIETRUSZKIEWICZ
Journal:  Biochim Biophys Acta       Date:  1960-08-26

2.  Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).

Authors:  V I OYAMA; H EAGLE
Journal:  Proc Soc Exp Biol Med       Date:  1956-02

3.  Synthesis of glycosaminoglycans by human embryonic lung fibroblasts. Different distribution of heparan sulphate, chondroitin sulphate and dermatan sulphate in various fractions of cell culture.

Authors:  I Sjöberg; L A Fransson
Journal:  Biochem J       Date:  1977-11-01       Impact factor: 3.857

4.  Extracellular, surface, and intracellular proteoglycans produced by human embryo lung fibroblasts in culture (IMR-90).

Authors:  K G Vogel; D W Peterson
Journal:  J Biol Chem       Date:  1981-12-25       Impact factor: 5.157

5.  Isolation and characterization of proteoglycans from bovine lung.

Authors:  B Radhakrishnamurthy; F Smart; E R Dalferes; G S Berenson
Journal:  J Biol Chem       Date:  1980-08-25       Impact factor: 5.157

6.  Connective tissue activation in guinea pig lung fibroblast cultures: regulatory effects of glucocorticoids.

Authors:  J C Seidman; C W Castor
Journal:  In Vitro       Date:  1981-02

7.  Connective tissue activation. XXI. Regulation of glycosaminoglycan metabolism by lymphocyte (CTAP-I) and platelet (CTAP-III) growth factors.

Authors:  C W Castor; M C Bignall; P A Hossler; D J Roberts
Journal:  In Vitro       Date:  1981-09

8.  Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein.

Authors:  N B Schwartz
Journal:  J Biol Chem       Date:  1977-09-25       Impact factor: 5.157

9.  Connective tissue formation by lung fibroblasts in vitro.

Authors:  C W Castor; P R Heiss; R H Gray; J C Seidman
Journal:  Am Rev Respir Dis       Date:  1979-07

10.  The glycosaminoglycans of the human artery and their changes in atherosclerosis.

Authors:  R L Stevens; M Colombo; J J Gonzales; W Hollander; K Schmid
Journal:  J Clin Invest       Date:  1976-08       Impact factor: 14.808
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