| Literature DB >> 8558530 |
L Davis1, G E Olsen, J T Klein, K J Kapples, F P Huger, C P Smith, W W Petko, M Cornfeldt, R C Effland.
Abstract
A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced dementia) as potential agents for the treatment of Alzheimer's disease. Compounds displaying significant activity were more broadly evaluated, which revealed the presence of a desirable adrenergic component of activity. The synthesis and structure-activity relationships for this series is presented, along with the biological profiles of selected compounds.Entities:
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Year: 1996 PMID： 8558530 DOI： 10.1021/jm950644v
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446