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Literature DB >> 8552591

Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

Abstract

Monoclonal antibody MAb K1 recognizes a 40-kDa glycoprotein present on the surface of mesothelial cells, mesotheliomas, and ovarian cancers. We have used MAb K1 to isolate a 2138-bp cDNA that encodes this antigen. The cDNA has an 1884-bp open reading frame encoding a 69-kDa protein. When the cDNA was transfected into COS and NIH 3T3 cells, the antigen was found on the cell surface and could be released by treatment with phosphatidylinositol-specific phospholipase C. The 69-kDa precursor is processed to the 40-kDa form. The protein has been named mesothelin because it is made by mesothelial cells. Mesothelin may play a role in cellular adhesion.

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Year: 1996 PMID： 8552591 PMCID： PMC40193 DOI： 10.1073/pnas.93.1.136

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

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Authors: K Chang; L H Pai; J K Batra; I Pastan; M C Willingham
Journal: Cancer Res Date: 1992-01-01 Impact factor: 12.701

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Journal: Nucleic Acids Res Date: 1987-10-26 Impact factor: 16.971

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Journal: Nature Date: 1987 Oct 29-Nov 4 Impact factor: 49.962

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Authors: I Stefanová; V Horejsí; I J Ansotegui; W Knapp; H Stockinger
Journal: Science Date: 1991-11-15 Impact factor: 47.728

6. Folate-binding protein is a marker for ovarian cancer.

Authors: I G Campbell; T A Jones; W D Foulkes; J Trowsdale
Journal: Cancer Res Date: 1991-10-01 Impact factor: 12.701

7. Evaluation of ricin A chain-containing immunotoxins directed against the CD30 antigen as potential reagents for the treatment of Hodgkin's disease.

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Journal: Cancer Res Date: 1990-01-01 Impact factor: 12.701

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Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

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Journal: J Immunol Date: 1987-06-01 Impact factor: 5.422

10. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.

Authors: R C Bast; T L Klug; E St John; E Jenison; J M Niloff; H Lazarus; R S Berkowitz; T Leavitt; C T Griffiths; L Parker; V R Zurawski; R C Knapp
Journal: N Engl J Med Date: 1983-10-13 Impact factor: 91.245

259 in total

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Journal: Clin Cancer Res Date: 2011-12-06 Impact factor: 12.531

2. Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.

Authors: Marie-Marthe Philippeaux; Jean-Claude Pache; Sophie Dahoun; Marc Barnet; John-Henri Robert; Jacques Mauël; Anastase Spiliopoulos
Journal: Histochem Cell Biol Date: 2004-09-15 Impact factor: 4.304

3. A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect.

Authors: A A V Paupoo; Z B Zhu; M Wang; D T Rein; A Starzinski-Powitz; D T Curiel
Journal: Hum Reprod Date: 2010-06-23 Impact factor: 6.918

4. A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas.

Authors: Sherrill L Macura; Jedd M Hillegass; Jeremy L Steinbacher; Maximilian B MacPherson; Arti Shukla; Stacie L Beuschel; Timothy N Perkins; Kelly J Butnor; Melissa J Lathrop; Mutlay Sayan; Khan Hekmatyar; Douglas J Taatjes; Risto A Kauppinen; Christopher C Landry; Brooke T Mossman
Journal: J Histochem Cytochem Date: 2012-06-21 Impact factor: 2.479