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Literature DB >> 8549789

Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide.

M M Mahoney¹, A Y Lee, D J Brezinski-Caliguri, K M Huttner.

Abstract

Cathelin-related genes are characterized by the presence of a prepro sequence which is highly conserved both within and between species. 3' RACE analysis on sheep bone marrow RNA, using a primer based on a conserved cathelin family coding region, demonstrated the presence of at least three ovine cathelin-related cDNAs. One of these encodes a novel prepropeptide with a predicted C-terminal cleavage product RGLRRLGRKIAHG-VKKYGPTVLRIIRIAG. The chemically synthesized form of this 29 amino acid peptide is shown to be a thermostable, broad spectrum, bactericidal agent.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1995 PMID： 8549789 DOI： 10.1016/0014-5793(95)01390-3

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

16 in total

1. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

Authors: V C Kalfa; H P Jia; R A Kunkle; P B McCray; B F Tack; K A Brogden
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

2. Antimicrobial activity and bacterial-membrane interaction of ovine-derived cathelicidins.

Authors: Rachel C Anderson; Robert E W Hancock; Pak-Lam Yu
Journal: Antimicrob Agents Chemother Date: 2004-02 Impact factor: 5.191

3. Inner field compensation as a tool for the characterization of asymmetric membranes and Peptide-membrane interactions.

Authors: Sven O Hagge; Andre Wiese; Ulrich Seydel; Thomas Gutsmann
Journal: Biophys J Date: 2004-02 Impact factor: 4.033

4. Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and atlantic salmon (Salmo salar).

Authors: Chin-I Chang; Yong-An Zhang; Jun Zou; Pin Nie; Christopher J Secombes
Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

5. Regulation of cathelicidin gene expression: induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar typhimurium infection.

Authors: H Wu; G Zhang; J E Minton; C R Ross; F Blecha
Journal: Infect Immun Date: 2000-10 Impact factor: 3.441

10. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

Authors: Z Oren; J C Lerman; G H Gudmundsson; B Agerberth; Y Shai
Journal: Biochem J Date: 1999-08-01 Impact factor: 3.857

Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide.

1. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

2. Antimicrobial activity and bacterial-membrane interaction of ovine-derived cathelicidins.

3. Inner field compensation as a tool for the characterization of asymmetric membranes and Peptide-membrane interactions.

4. Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and atlantic salmon (Salmo salar).

5. Regulation of cathelicidin gene expression: induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar typhimurium infection.

6. Cathelicidin gene expression in porcine tissues: roles in ontogeny and tissue specificity.

Review 7. Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

8. Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.

9. RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey.

10. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.