Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

Literature DB >> 11600395

Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

V C Kalfa¹, H P Jia, R A Kunkle, P B McCray, B F Tack, K A Brogden.

Abstract

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

Entities: Chemical Species

Mesh：

Substances：

Year: 2001 PMID： 11600395 PMCID： PMC90821 DOI： 10.1128/AAC.45.11.3256-3261.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. The outer membrane of Brucella ovis shows increased permeability to hydrophobic probes and is more susceptible to cationic peptides than are the outer membranes of mutant rough Brucella abortus strains.

Authors: E Freer; J Pizarro-Cerdá; A Weintraub; J A Bengoechea; I Moriyón; K Hultenby; J P Gorvel; E Moreno
Journal: Infect Immun Date: 1999-11 Impact factor: 3.441

2. cDNA sequences of three sheep myeloid cathelicidins.

Authors: L Bagella; M Scocchi; M Zanetti
Journal: FEBS Lett Date: 1995-12-04 Impact factor: 4.124

3. Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide.

Authors: M M Mahoney; A Y Lee; D J Brezinski-Caliguri; K M Huttner
Journal: FEBS Lett Date: 1995-12-27 Impact factor: 4.124

Review 4. How bacteria resist killing by host-defense peptides.

Authors: E A Groisman
Journal: Trends Microbiol Date: 1994-11 Impact factor: 17.079

5. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

Authors: Z Oren; J C Lerman; G H Gudmundsson; B Agerberth; Y Shai
Journal: Biochem J Date: 1999-08-01 Impact factor: 3.857

6. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.

Authors: K A Brogden; V C Kalfa; M R Ackermann; D E Palmquist; P B McCray; B F Tack
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

7. Bactericidal activity of mammalian cathelicidin-derived peptides.

Authors: S M Travis; N N Anderson; W R Forsyth; C Espiritu; B D Conway; E P Greenberg; P B McCray; R I Lehrer; M J Welsh; B F Tack
Journal: Infect Immun Date: 2000-05 Impact factor: 3.441

8. Pasteurella haemolytica lipopolysaccharide-associated protein induces pulmonary inflammation after bronchoscopic deposition in calves and sheep.

Authors: K A Brogden; M R Ackermann; B M Debey
Journal: Infect Immun Date: 1995-09 Impact factor: 3.441

9. Ovine pulmonary surfactant induces killing of Pasteurella haemolytica, Escherichia coli, and Klebsiella pneumoniae by normal serum.

Authors: K A Brogden
Journal: Infect Immun Date: 1992-12 Impact factor: 3.441

10. Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium.

Authors: C Parra-Lopez; M T Baer; E A Groisman
Journal: EMBO J Date: 1993-11 Impact factor: 11.598

22 in total

1. Communication: Antimicrobial Activity of SMAP28 with a Targeting Domain for Porphyromonas gingivalis.

Authors: Carol L Bratt; Karl G Kohlgraf; Katie Yohnke; Colleen Kummet; Deborah V Dawson; Kim A Brogden
Journal: Probiotics Antimicrob Proteins Date: 2010-03-01 Impact factor: 4.609

2. Driving engineering of novel antimicrobial peptides from simulations of peptide-micelle interactions.

Authors: Himanshu Khandelia; Allison A Langham; Yiannis N Kaznessis
Journal: Biochim Biophys Acta Date: 2006-05-15

3. Molecular dynamics investigation of the influence of anionic and zwitterionic interfaces on antimicrobial peptides' structure: implications for peptide toxicity and activity.

Authors: Himanshu Khandelia; Yiannis N Kaznessis
Journal: Peptides Date: 2005-12-01 Impact factor: 3.750

4. Cathelicidin administration protects mice from Bacillus anthracis spore challenge.

Authors: Mark W Lisanby; Melissa K Swiecki; Brian L P Dizon; Kathryn J Pflughoeft; Theresa M Koehler; John F Kearney
Journal: J Immunol Date: 2008-10-01 Impact factor: 5.422

Review 5. Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

Authors: Nicole K Brogden; Kim A Brogden
Journal: Int J Antimicrob Agents Date: 2011-07-05 Impact factor: 5.283

6. Towards a semantic lexicon for clinical natural language processing.

Authors: Hongfang Liu; Stephen T Wu; Dingcheng Li; Siddhartha Jonnalagadda; Sunghwan Sohn; Kavishwar Wagholikar; Peter J Haug; Stanley M Huff; Christopher G Chute
Journal: AMIA Annu Symp Proc Date: 2012-11-03

Review 7. What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?

Authors: Ernest Y Lee; Michelle W Lee; Benjamin M Fulan; Andrew L Ferguson; Gerard C L Wong
Journal: Interface Focus Date: 2017-10-20 Impact factor: 3.906