Literature DB >> 8547602

Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat.

Y Larmet1, S Reibel, J Carnahan, H Nawa, C Marescaux, A Depaulis.   

Abstract

Recent data have suggested the involvement of neurotrophins in the cascade of events occurring during seizure development. In particular, expression of both brain-derived neurotrophic factor (BDNF) and its receptor mRNAs increases in different brain structures after convulsive seizures. The physiological significance of this increase was investigated by chronic intrahippocampal perfusion of BDNF in the model of dorsal hippocampal kindling in the rat. A 7 day perfusion of BDNF, in the region of the stimulating electrode, blocked the development of kindling during the perfusion period and for the following 15 days. These results provide in vivo evidence for a protective role of BDNF in the regulation of plasticity involved in epileptogenesis in adult brain.

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Year:  1995        PMID： 8547602     DOI： 10.1097/00001756-199510020-00027

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  16 in total

Review 1.  Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.

Authors:  Brian R Christie; Brennan D Eadie; Timal S Kannangara; Julie M Robillard; James Shin; Andrea K Titterness
Journal:  Neuromolecular Med       Date:  2008-06-06       Impact factor: 3.843

Review 2.  Is epilepsy a preventable disorder? New evidence from animal models.

Authors:  Kathryn A Giblin; Hal Blumenfeld
Journal:  Neuroscientist       Date:  2010-06       Impact factor: 7.519

3.  Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.

Authors:  S D Croll; C Suri; D L Compton; M V Simmons; G D Yancopoulos; R M Lindsay; S J Wiegand; J S Rudge; H E Scharfman
Journal:  Neuroscience       Date:  1999       Impact factor: 3.590

4.  Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice.

Authors:  Kate L Weidner; Jeffrey H Goodman; Kathryn K Chadman; Daniel P McCloskey
Journal:  Aging Dis       Date:  2011-08-30       Impact factor: 6.745

5.  Brain-derived neurotrophic factor and epilepsy--a missing link?

Authors:  Helen E Scharfman
Journal:  Epilepsy Curr       Date:  2005 May-Jun       Impact factor: 7.500

Review 6.  Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS.

Authors:  Helen E Scharfman; Neil J MacLusky
Journal:  Front Neuroendocrinol       Date:  2006-10-20       Impact factor: 8.606

Review 7.  Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?

Authors:  L Cardamone; M R Salzberg; T J O'Brien; N C Jones
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

8.  Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor.

Authors:  Helen E Scharfman; Thomas C Mercurio; Jeffrey H Goodman; Marlene A Wilson; Neil J MacLusky
Journal:  J Neurosci       Date:  2003-12-17       Impact factor: 6.167

Review 9.  Gene expression profiling of seizure disorders.

Authors:  Robert C Elliott; Daniel H Lowenstein
Journal:  Neurochem Res       Date:  2004-06       Impact factor: 3.996

10.  Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.

Authors:  D K Binder; M J Routbort; T E Ryan; G D Yancopoulos; J O McNamara
Journal:  J Neurosci       Date:  1999-02-15       Impact factor: 6.167
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