Literature DB >> 18535925

Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.

Brian R Christie1, Brennan D Eadie, Timal S Kannangara, Julie M Robillard, James Shin, Andrea K Titterness.   

Abstract

Exercise that engages the cardiovascular system has a myriad of effects on the body; however, we usually do not give much consideration to the benefits it may have for our minds. An increasing body of evidence suggests that exercise can have some remarkable effects on the brain. In this article, we will introduce how exercise can impact the capacity for neurons in the brain to communicate with one another. To properly convey this information, we will first briefly introduce the field of synaptic plasticity and then examine how the introduction of exercise to the experimental setting can actually alter the basic properties of synaptic plasticity in the brain. Next, we will examine some of the candidate physiological processes that might underlay these alterations. Finally, we will close by noting that, taken together, this data points toward our brains being dynamic systems that are in a continual state of flux and that physical exercise may help us to maximize the performance of both our body and our minds.

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Year:  2008        PMID: 18535925     DOI: 10.1007/s12017-008-8033-2

Source DB:  PubMed          Journal:  Neuromolecular Med        ISSN: 1535-1084            Impact factor:   3.843


  122 in total

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4.  Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat.

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5.  Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

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Journal:  J Biol Chem       Date:  2001-01-10       Impact factor: 5.157

6.  Cognitive status, stroke symptom reports, and modifiable risk factors among individuals with no diagnosis of stroke or transient ischemic attack in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

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Journal:  Stroke       Date:  2007-02-22       Impact factor: 7.914

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Journal:  J Neurosci       Date:  1995-03       Impact factor: 6.167

9.  Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat.

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10.  Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.

Authors:  J Farmer; X Zhao; H van Praag; K Wodtke; F H Gage; B R Christie
Journal:  Neuroscience       Date:  2004       Impact factor: 3.590

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  40 in total

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Journal:  Hippocampus       Date:  2009-10       Impact factor: 3.899

3.  Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.

Authors:  Ruchika Shaurya Prakash; Erin M Snook; Robert W Motl; Arthur F Kramer
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4.  Antidepressant and proneurogenic influence of environmental enrichment in mice: protective effects vs recovery.

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Review 5.  A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.

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Journal:  J Psychiatr Res       Date:  2014-10-12       Impact factor: 4.791

Review 6.  Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia.

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7.  Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress.

Authors:  David Gozal; Deepti Nair; Aviv D Goldbart
Journal:  Am J Respir Crit Care Med       Date:  2010-03-11       Impact factor: 21.405

Review 8.  Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose.

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9.  Poorer physical fitness is associated with reduced structural brain integrity in heart failure.

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Journal:  Brain Behav Immun       Date:  2012-11-02       Impact factor: 7.217

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