| Literature DB >> 8547072 |
H Myint1, J A Copplestone, J Orchard, V Craig, D Curtis, A G Prentice, M D Hamon, D G Oscier, T J Hamblin.
Abstract
We have treated 52 patients with chronic lymphocytic leukaemia (CLL) with fludarabine; 12 developed severe autoimmune haemolysis. Only three had a previous history of haemolytic anaemia. Six out of eight patients retreated with fludarabine after control of their haemolysis developed an exacerbation of the haemolytic anaemia. The cause of autoimmune phenomena in CLL is not known, but our findings reinforce the view that they are caused by a disturbance in immunoregulatory T cells. Fludarabine is a known suppressor of T-cell function.Entities:
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Year: 1995 PMID： 8547072 DOI： 10.1111/j.1365-2141.1995.tb05300.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998