| Literature DB >> 19811329 |
Clive S Zent1, Wei Ding, Megan S Reinalda, Susan M Schwager, James D Hoyer, Deborah A Bowen, Diane F Jelinek, Renee C Tschumper, Timothy G Call, Tait D Shanafelt, Neil E Kay, Susan L Slager.
Abstract
Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) complicated by autoimmune disease cytopenia (AID cytopenia). We reviewed the clinical characteristics, treatment, and outcome of AID cytopenia that was diagnosed in 75 (4.3%) of 1750 patients with CLL seen at a single institution over 10 years. When compared with the historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%), and pure red blood cell aplasia (0.5%). AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients. We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients.Entities:
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Year: 2009 PMID： 19811329 PMCID： PMC3917557 DOI： 10.1080/10428190903026492
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022